DNAJB12 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071218Biological processcellular response to misfolded protein
GO_0051085Biological processchaperone cofactor-dependent protein refolding
GO_0036503Biological processERAD pathway
GO_0065003Biological processprotein-containing complex assembly
GO_0005783Cellular componentendoplasmic reticulum
GO_0031965Cellular componentnuclear membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0030544Molecular functionHsp70 protein binding

IV. Literature review

[source]
Gene nameDNAJB12
Protein nameDnaJ homolog subfamily B member 12
DnaJ (Hsp40) homolog, subfamily B, member 12, isoform CRA_c (DnaJ heat shock protein family (Hsp40) member B12)
DnaJ heat shock protein family (Hsp40) member B12
SynonymshCG_2024622
DescriptionFUNCTION: Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway . Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities . Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers . While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 . When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear . .; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection . .

AccessionsENST00000463786.2
J3KPS0
ENST00000338820.7
ENST00000461919.5
ENST00000444643.8 [Q9NXW2-1]
ENST00000394903.6
V9GYN7
Q9NXW2
V9GY70