DNAI3 | OmnibusX

Name	Number of supported studies	Average coverage
ciliated cell	16 studies	40% ± 10%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of DNAI3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	88%	77.86	1589 / 1809	66%	7.68	310 / 472
thymus	93%	62.41	608 / 653	47%	0.97	286 / 605
adrenal gland	100%	1693.74	258 / 258	37%	3.94	85 / 230
kidney	97%	59.84	86 / 89	30%	0.65	266 / 901
lung	94%	205.41	541 / 578	23%	0.83	260 / 1155
uterus	49%	55.34	84 / 170	22%	0.76	103 / 459
breast	46%	15.40	211 / 459	21%	0.51	237 / 1118
heart	64%	48.34	548 / 861	0%	0	0 / 0
brain	39%	71.55	1038 / 2642	23%	1.08	159 / 705
eye	0%	0	0 / 0	55%	1.23	44 / 80
prostate	45%	18.78	111 / 245	6%	0.17	32 / 502
ovary	12%	3.94	22 / 180	27%	0.94	115 / 430
esophagus	28%	9.04	410 / 1445	3%	0.07	5 / 183
spleen	31%	8.95	74 / 241	0%	0	0 / 0
adipose	26%	7.74	310 / 1204	0%	0	0 / 0
peripheral blood	25%	31.35	235 / 929	0%	0	0 / 0
intestine	21%	5.63	204 / 966	3%	0.08	18 / 527
bladder	10%	2.00	2 / 21	8%	0.17	40 / 504
lymph node	0%	0	0 / 0	17%	0.37	5 / 29
stomach	13%	3.15	45 / 359	3%	0.04	8 / 286
blood vessel	14%	4.04	185 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	13%	0.16	6 / 45
pancreas	5%	1.35	16 / 328	8%	0.25	15 / 178
muscle	4%	1.30	36 / 803	0%	0	0 / 0
liver	0%	0.20	1 / 226	2%	0.04	8 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0034316	Biological process	negative regulation of Arp2/3 complex-mediated actin nucleation
GO_0030336	Biological process	negative regulation of cell migration
GO_0060294	Biological process	cilium movement involved in cell motility
GO_0045669	Biological process	positive regulation of osteoblast differentiation
GO_0036159	Biological process	inner dynein arm assembly
GO_0036156	Cellular component	inner dynein arm
GO_0005858	Cellular component	axonemal dynein complex
GO_0005737	Cellular component	cytoplasm
GO_0045503	Molecular function	dynein light chain binding
GO_0005515	Molecular function	protein binding
GO_0071933	Molecular function	Arp2/3 complex binding
GO_0045504	Molecular function	dynein heavy chain binding

Gene name	DNAI3
Protein name	Dynein axonemal intermediate chain 3 (Testis development protein NYD-SP29) (WD repeat-containing protein 63) Alternative protein WDR63 Dynein axonemal intermediate chain 3
Synonyms	WDR63
Description	FUNCTION: Acts as a negative regulator of cell migration, invasion, and metastasis downstream of p53/TP53, through inhibition of Arp2/3 complex-mediated actin polymerization . Via its association with the multisubunit axonemal dynein complex, is potentially involved in the regulation of cilia function (By similarity). May play a role in osteogenesis of dental tissue-derived mesenchymal stem cells (By similarity). .
Accessions	ENST00000294664.11 [Q8IWG1-1] E9PLW4 ENST00000464801.1 Q8IWG1 H0YEC9 ENST00000528899.5 ENST00000484007.1 L8E9L7 ENST00000326813.12 [Q8IWG1-2] E9PLK2 ENST00000370596.5 [Q8IWG1-2]

DNAI3 report