I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| smooth muscle cell | 7 studies | 21% ± 6% | |
| astrocyte | 3 studies | 28% ± 2% | |
| oligodendrocyte precursor cell | 3 studies | 19% ± 2% | |
| pericyte | 3 studies | 18% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| smooth muscle cell | 7 studies | 21% ± 6% | |
| astrocyte | 3 studies | 28% ± 2% | |
| oligodendrocyte precursor cell | 3 studies | 19% ± 2% | |
| pericyte | 3 studies | 18% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 23% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| adrenal gland | 100% | 11879.83 | 258 / 258 | 100% | 31.91 | 230 / 230 |
| uterus | 100% | 14201.09 | 170 / 170 | 100% | 22.20 | 458 / 459 |
| prostate | 100% | 12009.78 | 244 / 245 | 100% | 19.74 | 500 / 502 |
| esophagus | 99% | 18250.33 | 1426 / 1445 | 100% | 14.72 | 183 / 183 |
| bladder | 100% | 12320.00 | 21 / 21 | 99% | 16.18 | 497 / 504 |
| breast | 99% | 5026.76 | 455 / 459 | 98% | 14.03 | 1097 / 1118 |
| thymus | 99% | 6729.04 | 649 / 653 | 98% | 10.11 | 591 / 605 |
| ovary | 100% | 7228.89 | 180 / 180 | 97% | 12.22 | 417 / 430 |
| brain | 95% | 4933.29 | 2507 / 2642 | 100% | 30.86 | 705 / 705 |
| intestine | 96% | 14184.00 | 925 / 966 | 97% | 10.95 | 513 / 527 |
| lung | 98% | 6426.93 | 569 / 578 | 94% | 11.45 | 1088 / 1155 |
| kidney | 96% | 5125.04 | 85 / 89 | 94% | 10.84 | 850 / 901 |
| stomach | 94% | 8331.39 | 337 / 359 | 93% | 13.03 | 267 / 286 |
| skin | 87% | 3376.75 | 1566 / 1809 | 96% | 13.64 | 454 / 472 |
| pancreas | 81% | 3405.88 | 265 / 328 | 100% | 16.81 | 178 / 178 |
| blood vessel | 100% | 19471.99 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 22.04 | 1 / 1 |
| muscle | 100% | 15741.67 | 802 / 803 | 0% | 0 | 0 / 0 |
| spleen | 99% | 5320.14 | 239 / 241 | 0% | 0 | 0 / 0 |
| adipose | 98% | 5526.74 | 1184 / 1204 | 0% | 0 | 0 / 0 |
| heart | 98% | 17551.24 | 844 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 14.76 | 44 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 10.16 | 28 / 29 |
| eye | 0% | 0 | 0 / 0 | 96% | 8.89 | 77 / 80 |
| liver | 6% | 157.92 | 13 / 226 | 60% | 4.98 | 243 / 406 |
| peripheral blood | 12% | 350.47 | 116 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0018105 | Biological process | peptidyl-serine phosphorylation |
| GO_0002028 | Biological process | regulation of sodium ion transport |
| GO_0006998 | Biological process | nuclear envelope organization |
| GO_0051823 | Biological process | regulation of synapse structural plasticity |
| GO_0014853 | Biological process | regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction |
| GO_0010657 | Biological process | muscle cell apoptotic process |
| GO_0006874 | Biological process | intracellular calcium ion homeostasis |
| GO_0010830 | Biological process | regulation of myotube differentiation |
| GO_0014722 | Biological process | regulation of skeletal muscle contraction by calcium ion signaling |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0008016 | Biological process | regulation of heart contraction |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005640 | Cellular component | nuclear outer membrane |
| GO_0005829 | Cellular component | cytosol |
| GO_0005741 | Cellular component | mitochondrial outer membrane |
| GO_0033017 | Cellular component | sarcoplasmic reticulum membrane |
| GO_0031965 | Cellular component | nuclear membrane |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0017020 | Molecular function | myosin phosphatase regulator activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | DMPK |
| Protein name | non-specific serine/threonine protein kinase (EC 2.7.11.1) DM1 protein kinase Myotonin-protein kinase (MT-PK) (EC 2.7.11.1) (DM-kinase) (DMK) (DM1 protein kinase) (DMPK) (Myotonic dystrophy protein kinase) |
| Synonyms | hCG_1996612 MDPK DM1PK |
| Description | FUNCTION: Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity. . |
| Accessions | ENST00000343373.10 [Q09013-16] ENST00000447742.6 [Q09013-11] Q09013 I6L989 M0R1F3 ENST00000458663.6 [Q09013-15] ENST00000588522.5 ENST00000354227.9 [Q09013-12] ENST00000683086.1 [Q09013-10] ENST00000597660.1 E5KR07 ENST00000291270.9 [Q09013-9] K7EQX1 ENST00000593574.1 M0QXJ9 X5DNJ6 X5D8Z6 |
