DIMT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000234Biological processpositive regulation of rRNA processing
GO_0031167Biological processrRNA methylation
GO_0042274Biological processribosomal small subunit biogenesis
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0032040Cellular componentsmall-subunit processome
GO_0000179Molecular functionrRNA (adenine-N6,N6-)-dimethyltransferase activity
GO_0052909Molecular function18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameDIMT1
Protein nameDIM1 rRNA methyltransferase and ribosome maturation factor
rRNA adenine N(6)-methyltransferase (EC 2.1.1.-)
Probable dimethyladenosine transferase (EC 2.1.1.183) (DIM1 dimethyladenosine transferase 1 homolog) (DIM1 dimethyladenosine transferase 1-like) (Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase) (Probable 18S rRNA dimethylase) (Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase)
SynonymsDIMT1L
HUSSY-05
DescriptionFUNCTION: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle . Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity . Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome . .

AccessionsQ9UNQ2
A0A7P0T967
ENST00000679751.1
ENST00000680062.1
A0A7P0T8X7
ENST00000681393.1
A0A7P0T9J1
ENST00000681192.1
D6RCL3
ENST00000514911.5
ENST00000199320.9
ENST00000651114.1
ENST00000681272.1
ENST00000506390.5
A0A0C4DGB1
ENST00000680960.1
ENST00000681672.1
A0A7P0T9Y7
A0A7P0Z4I0
B4DRY2
A0A494C0G7