I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 5 studies | 36% ± 22% | |
| type I pneumocyte | 5 studies | 28% ± 7% | |
| epithelial cell | 3 studies | 26% ± 10% | |
| transit amplifying cell | 3 studies | 51% ± 23% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| astrocyte | 5 studies | 36% ± 22% | |
| type I pneumocyte | 5 studies | 28% ± 7% | |
| epithelial cell | 3 studies | 26% ± 10% | |
| transit amplifying cell | 3 studies | 51% ± 23% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| liver | 3 studies | 20% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 94% | 837.47 | 1708 / 1809 | 84% | 7.17 | 396 / 472 |
| stomach | 81% | 229.17 | 291 / 359 | 94% | 7.76 | 270 / 286 |
| lung | 91% | 192.99 | 528 / 578 | 79% | 4.64 | 917 / 1155 |
| esophagus | 50% | 172.47 | 726 / 1445 | 95% | 8.19 | 174 / 183 |
| intestine | 50% | 85.46 | 487 / 966 | 94% | 8.22 | 494 / 527 |
| kidney | 87% | 116.92 | 77 / 89 | 37% | 1.56 | 336 / 901 |
| brain | 74% | 102.97 | 1963 / 2642 | 36% | 1.51 | 254 / 705 |
| uterus | 16% | 20.38 | 27 / 170 | 94% | 8.36 | 432 / 459 |
| breast | 25% | 22.43 | 114 / 459 | 80% | 5.51 | 889 / 1118 |
| ovary | 12% | 20.17 | 21 / 180 | 83% | 4.27 | 356 / 430 |
| tonsil | 0% | 0 | 0 / 0 | 93% | 6.60 | 42 / 45 |
| bladder | 10% | 6.81 | 2 / 21 | 83% | 6.17 | 416 / 504 |
| lymph node | 0% | 0 | 0 / 0 | 86% | 4.94 | 25 / 29 |
| blood vessel | 82% | 216.13 | 1101 / 1335 | 0% | 0 | 0 / 0 |
| pancreas | 18% | 14.35 | 58 / 328 | 60% | 2.38 | 106 / 178 |
| spleen | 70% | 112.56 | 168 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 44% | 484.26 | 408 / 929 | 0% | 0 | 0 / 0 |
| adrenal gland | 26% | 21.51 | 66 / 258 | 16% | 0.72 | 36 / 230 |
| adipose | 38% | 55.08 | 463 / 1204 | 0% | 0 | 0 / 0 |
| liver | 8% | 9.19 | 18 / 226 | 22% | 1.16 | 88 / 406 |
| thymus | 12% | 8.31 | 77 / 653 | 12% | 0.67 | 72 / 605 |
| prostate | 13% | 10.76 | 31 / 245 | 4% | 0.17 | 22 / 502 |
| heart | 12% | 13.11 | 106 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 4% | 0.09 | 3 / 80 |
| muscle | 0% | 0.44 | 3 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0030010 | Biological process | establishment of cell polarity |
| GO_0007605 | Biological process | sensory perception of sound |
| GO_0060322 | Biological process | head development |
| GO_0001701 | Biological process | in utero embryonic development |
| GO_0061909 | Biological process | autophagosome-lysosome fusion |
| GO_0007059 | Biological process | chromosome segregation |
| GO_0034367 | Biological process | protein-containing complex remodeling |
| GO_0030225 | Biological process | macrophage differentiation |
| GO_0030041 | Biological process | actin filament polymerization |
| GO_0007010 | Biological process | cytoskeleton organization |
| GO_0030030 | Biological process | cell projection organization |
| GO_0045010 | Biological process | actin nucleation |
| GO_0007026 | Biological process | negative regulation of microtubule depolymerization |
| GO_0051017 | Biological process | actin filament bundle assembly |
| GO_0071800 | Biological process | podosome assembly |
| GO_0030036 | Biological process | actin cytoskeleton organization |
| GO_0007229 | Biological process | integrin-mediated signaling pathway |
| GO_0016197 | Biological process | endosomal transport |
| GO_0046785 | Biological process | microtubule polymerization |
| GO_0051764 | Biological process | actin crosslink formation |
| GO_0060113 | Biological process | inner ear receptor cell differentiation |
| GO_0010467 | Biological process | gene expression |
| GO_0043131 | Biological process | erythrocyte enucleation |
| GO_0031941 | Cellular component | filamentous actin |
| GO_0032432 | Cellular component | actin filament bundle |
| GO_0000922 | Cellular component | spindle pole |
| GO_0005815 | Cellular component | microtubule organizing center |
| GO_0000813 | Cellular component | ESCRT I complex |
| GO_0005884 | Cellular component | actin filament |
| GO_0097470 | Cellular component | ribbon synapse |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_1990427 | Cellular component | stereocilia tip-link density |
| GO_0032154 | Cellular component | cleavage furrow |
| GO_0005634 | Cellular component | nucleus |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0045296 | Molecular function | cadherin binding |
| GO_0031267 | Molecular function | small GTPase binding |
| GO_0008017 | Molecular function | microtubule binding |
| GO_0003779 | Molecular function | actin binding |
| Gene name | DIAPH3 |
| Protein name | Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (MDia2) |
| Synonyms | DIAP3 |
| Description | FUNCTION: Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity. . |
| Accessions | ENST00000465066.5 [Q9NSV4-1] ENST00000377908.6 [Q9NSV4-4] ENST00000400319.5 [Q9NSV4-6] ENST00000400324.9 [Q9NSV4-3] Q9NSV4 ENST00000267215.8 [Q9NSV4-7] ENST00000400320.5 [Q9NSV4-5] ENST00000498416.2 [Q9NSV4-2] |
