Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 9 studies | 37% ± 23% | |
T cell | 8 studies | 23% ± 6% | |
B cell | 6 studies | 28% ± 9% | |
glutamatergic neuron | 6 studies | 22% ± 5% | |
plasmablast | 5 studies | 36% ± 18% | |
erythroblast | 5 studies | 38% ± 20% | |
erythrocyte | 5 studies | 47% ± 15% | |
natural killer cell | 5 studies | 34% ± 12% | |
pro-B cell | 4 studies | 29% ± 13% | |
epithelial cell | 4 studies | 28% ± 4% | |
dendritic cell | 4 studies | 31% ± 15% | |
CD8-positive, alpha-beta T cell | 4 studies | 30% ± 2% | |
deuterosomal cell | 3 studies | 22% ± 4% | |
cholangiocyte | 3 studies | 21% ± 4% | |
macrophage | 3 studies | 52% ± 24% | |
hepatocyte | 3 studies | 21% ± 1% | |
neuron | 3 studies | 33% ± 22% | |
fibroblast | 3 studies | 40% ± 21% | |
ciliated cell | 3 studies | 32% ± 22% | |
hematopoietic precursor cell | 3 studies | 26% ± 5% | |
astrocyte | 3 studies | 26% ± 12% | |
CD4-positive, alpha-beta T cell | 3 studies | 37% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 99% | 497.38 | 1436 / 1445 | 100% | 16.43 | 183 / 183 |
brain | 100% | 722.44 | 2637 / 2642 | 99% | 20.06 | 701 / 705 |
intestine | 100% | 612.88 | 964 / 966 | 99% | 16.63 | 521 / 527 |
ovary | 99% | 339.48 | 179 / 180 | 99% | 15.10 | 426 / 430 |
breast | 99% | 542.19 | 455 / 459 | 98% | 15.70 | 1096 / 1118 |
uterus | 99% | 379.22 | 168 / 170 | 97% | 19.57 | 446 / 459 |
bladder | 100% | 436.33 | 21 / 21 | 94% | 12.06 | 472 / 504 |
lung | 94% | 362.88 | 545 / 578 | 98% | 11.14 | 1136 / 1155 |
liver | 100% | 642.53 | 225 / 226 | 91% | 10.78 | 370 / 406 |
thymus | 99% | 385.54 | 647 / 653 | 90% | 7.93 | 546 / 605 |
prostate | 99% | 412.09 | 243 / 245 | 90% | 7.81 | 451 / 502 |
skin | 94% | 896.86 | 1703 / 1809 | 95% | 15.66 | 447 / 472 |
stomach | 88% | 296.72 | 316 / 359 | 99% | 16.40 | 284 / 286 |
kidney | 100% | 579.21 | 89 / 89 | 84% | 7.20 | 758 / 901 |
adrenal gland | 96% | 385.25 | 247 / 258 | 80% | 6.02 | 185 / 230 |
pancreas | 35% | 54.85 | 114 / 328 | 89% | 6.35 | 159 / 178 |
lymph node | 0% | 0 | 0 / 0 | 100% | 19.83 | 29 / 29 |
spleen | 100% | 633.33 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 28.56 | 45 / 45 |
adipose | 100% | 635.85 | 1202 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 386.31 | 1328 / 1335 | 0% | 0 | 0 / 0 |
muscle | 96% | 433.94 | 771 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 87% | 940.78 | 809 / 929 | 0% | 0 | 0 / 0 |
heart | 84% | 251.69 | 726 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 73% | 5.80 | 58 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0031103 | Biological process | axon regeneration |
GO_0006729 | Biological process | tetrahydrobiopterin biosynthetic process |
GO_0006730 | Biological process | one-carbon metabolic process |
GO_0046655 | Biological process | folic acid metabolic process |
GO_2000121 | Biological process | regulation of removal of superoxide radicals |
GO_0046653 | Biological process | tetrahydrofolate metabolic process |
GO_0046654 | Biological process | tetrahydrofolate biosynthetic process |
GO_0031427 | Biological process | response to methotrexate |
GO_0046452 | Biological process | dihydrofolate metabolic process |
GO_0051000 | Biological process | positive regulation of nitric-oxide synthase activity |
GO_0017148 | Biological process | negative regulation of translation |
GO_0005739 | Cellular component | mitochondrion |
GO_0005829 | Cellular component | cytosol |
GO_1990825 | Molecular function | sequence-specific mRNA binding |
GO_0004146 | Molecular function | dihydrofolate reductase activity |
GO_0000900 | Molecular function | mRNA regulatory element binding translation repressor activity |
GO_0003729 | Molecular function | mRNA binding |
GO_0050661 | Molecular function | NADP binding |
GO_0070402 | Molecular function | NADPH binding |
GO_0005542 | Molecular function | folic acid binding |
Gene name | DHFR |
Protein name | Dihydrofolate reductase (EC 1.5.1.3) |
Synonyms | DYR |
Description | FUNCTION: Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2. . |
Accessions | P00374 B4DM58 B0YJ76 ENST00000505337.5 [P00374-1] ENST00000504396.1 [P00374-2] ENST00000511032.5 ENST00000439211.7 [P00374-1] |