DHFR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031103Biological processaxon regeneration
GO_0006729Biological processtetrahydrobiopterin biosynthetic process
GO_0006730Biological processone-carbon metabolic process
GO_0046655Biological processfolic acid metabolic process
GO_2000121Biological processregulation of removal of superoxide radicals
GO_0046653Biological processtetrahydrofolate metabolic process
GO_0046654Biological processtetrahydrofolate biosynthetic process
GO_0031427Biological processresponse to methotrexate
GO_0046452Biological processdihydrofolate metabolic process
GO_0051000Biological processpositive regulation of nitric-oxide synthase activity
GO_0017148Biological processnegative regulation of translation
GO_0005739Cellular componentmitochondrion
GO_0005829Cellular componentcytosol
GO_1990825Molecular functionsequence-specific mRNA binding
GO_0004146Molecular functiondihydrofolate reductase activity
GO_0000900Molecular functionmRNA regulatory element binding translation repressor activity
GO_0003729Molecular functionmRNA binding
GO_0050661Molecular functionNADP binding
GO_0070402Molecular functionNADPH binding
GO_0005542Molecular functionfolic acid binding

IV. Literature review

[source]
Gene nameDHFR
Protein nameDihydrofolate reductase (EC 1.5.1.3)
SynonymsDYR
DescriptionFUNCTION: Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2. .

AccessionsP00374
B4DM58
B0YJ76
ENST00000505337.5 [P00374-1]
ENST00000504396.1 [P00374-2]
ENST00000511032.5
ENST00000439211.7 [P00374-1]