DGKG report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006654Biological processphosphatidic acid biosynthetic process
GO_0046339Biological processdiacylglycerol metabolic process
GO_0090038Biological processnegative regulation of protein kinase C signaling
GO_0035556Biological processintracellular signal transduction
GO_0046486Biological processglycerolipid metabolic process
GO_0048666Biological processneuron development
GO_0030168Biological processplatelet activation
GO_0046834Biological processlipid phosphorylation
GO_0050773Biological processregulation of dendrite development
GO_0007205Biological processprotein kinase C-activating G protein-coupled receptor signaling pathway
GO_0005856Cellular componentcytoskeleton
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0005886Cellular componentplasma membrane
GO_0005509Molecular functioncalcium ion binding
GO_0004143Molecular functionATP-dependent diacylglycerol kinase activity
GO_0008289Molecular functionlipid binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameDGKG
Protein nameDiacylglycerol kinase gamma (DAG kinase gamma) (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma)
Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107)
Diacylglycerol kinase gamma
SynonymsDAGK3
DescriptionFUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids . Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (By similarity). Has no apparent specificity with regard to the acyl compositions of diacylglycerol . Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma. Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination (By similarity). .

AccessionsENST00000265022.8 [P49619-1]
ENST00000382164.8 [P49619-3]
H7C0L0
P49619
ENST00000344484.8 [P49619-2]
ENST00000437018.2
Q2M589