DGAT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006640Biological processmonoacylglycerol biosynthetic process
GO_0055089Biological processfatty acid homeostasis
GO_0035336Biological processlong-chain fatty-acyl-CoA metabolic process
GO_0046339Biological processdiacylglycerol metabolic process
GO_0034379Biological processvery-low-density lipoprotein particle assembly
GO_0019432Biological processtriglyceride biosynthetic process
GO_0019915Biological processlipid storage
GO_0042572Biological processretinol metabolic process
GO_0006641Biological processtriglyceride metabolic process
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0003846Molecular function2-acylglycerol O-acyltransferase activity
GO_0016746Molecular functionacyltransferase activity
GO_0042802Molecular functionidentical protein binding
GO_0004144Molecular functiondiacylglycerol O-acyltransferase activity
GO_0050252Molecular functionretinol O-fatty-acyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDGAT1
Protein nameDiacylglycerol O-acyltransferase 1 (EC 2.3.1.20) (EC 2.3.1.76) (Acyl-CoA retinol O-fatty-acyltransferase) (Diglyceride acyltransferase)
DGAT1 protein
diacylglycerol O-acyltransferase (EC 2.3.1.20)
Diacylglycerol O-acyltransferase 1 (EC 2.3.1.20) (ACAT-related gene product 1) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase)
SynonymsAGRP1
DGAT
DescriptionFUNCTION: Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates . Highly expressed in epithelial cells of the small intestine and its activity is essential for the absorption of dietary fats . In liver, plays a role in esterifying exogenous fatty acids to glycerol, and is required to synthesize fat for storage . Also present in female mammary glands, where it produces fat in the milk (By similarity). May be involved in VLDL (very low density lipoprotein) assembly . In contrast to DGAT2 it is not essential for survival (By similarity). Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders . Exhibits additional acyltransferase activities, includin acyl CoA:monoacylglycerol acyltransferase (MGAT), wax monoester and wax diester synthases (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) . .

AccessionsO75907
A0A0A0MR74
Q9BRH5
ENST00000332324.5
ENST00000528718.6
Q3KQR6
ENST00000644790.2