DEPTOR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032007Biological processnegative regulation of TOR signaling
GO_0035556Biological processintracellular signal transduction
GO_0006469Biological processnegative regulation of protein kinase activity
GO_0045792Biological processnegative regulation of cell size
GO_0010508Biological processpositive regulation of autophagy
GO_1903940Biological processnegative regulation of TORC2 signaling
GO_2001236Biological processregulation of extrinsic apoptotic signaling pathway
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0005765Cellular componentlysosomal membrane
GO_0004860Molecular functionprotein kinase inhibitor activity
GO_0070300Molecular functionphosphatidic acid binding
GO_0030291Molecular functionprotein serine/threonine kinase inhibitor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDEPTOR
Protein nameDEP domain-containing mTOR-interacting protein (hDEPTOR) (DEP domain-containing protein 6)
SynonymsDEPDC6
DescriptionFUNCTION: Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes . DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy . In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity . .

AccessionsENST00000523492.5 [Q8TB45-2]
ENST00000286234.6 [Q8TB45-1]
Q8TB45