DEFB114 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DEFB114 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DEFB114 at tissue level.

III. Associated gene sets

GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0043407Biological processnegative regulation of MAP kinase activity
GO_0061760Biological processantifungal innate immune response
GO_0050729Biological processpositive regulation of inflammatory response
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0060326Biological processcell chemotaxis
GO_0042742Biological processdefense response to bacterium
GO_0045087Biological processinnate immune response
GO_0050918Biological processpositive chemotaxis
GO_0031665Biological processnegative regulation of lipopolysaccharide-mediated signaling pathway
GO_0005615Cellular componentextracellular space
GO_0042056Molecular functionchemoattractant activity
GO_0001530Molecular functionlipopolysaccharide binding
GO_0031731Molecular functionCCR6 chemokine receptor binding

IV. Literature review

[source]
Gene nameDEFB114
Protein nameBeta-defensin 114 (Beta-defensin 14) (DEFB-14) (Defensin, beta 114)
SynonymsDEFB14
DescriptionFUNCTION: Has a salt-sensitive antimicrobial activity against Gram-negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality. .

AccessionsQ30KQ6
ENST00000322066.4