DEFA4 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of DEFA4 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
spleen	93%	978.23	224 / 241	0%	0	0 / 0
peripheral blood	81%	3794.52	751 / 929	0%	0	0 / 0
lung	78%	293.34	452 / 578	1%	0.28	16 / 1155
liver	22%	26.14	50 / 226	5%	0.15	19 / 406
thymus	12%	6.08	78 / 653	11%	1.17	66 / 605
heart	15%	12.65	133 / 861	0%	0	0 / 0
adipose	14%	8.70	167 / 1204	0%	0	0 / 0
breast	13%	6.29	58 / 459	1%	0.01	7 / 1118
adrenal gland	2%	0.83	6 / 258	7%	4.40	16 / 230
kidney	6%	2.02	5 / 89	3%	0.17	29 / 901
brain	6%	2.52	156 / 2642	2%	0.08	13 / 705
lymph node	0%	0	0 / 0	7%	0.10	2 / 29
muscle	5%	2.50	42 / 803	0%	0	0 / 0
blood vessel	3%	2.45	45 / 1335	0%	0	0 / 0
intestine	2%	5.85	21 / 966	1%	0.02	4 / 527
esophagus	2%	1.45	30 / 1445	1%	0.05	1 / 183
stomach	1%	0.77	4 / 359	1%	0.04	4 / 286
pancreas	0%	0.31	1 / 328	2%	0.02	3 / 178
uterus	2%	1.18	3 / 170	0%	0	0 / 459
skin	0%	0.11	4 / 1809	1%	0.02	6 / 472
ovary	1%	0.32	2 / 180	0%	0.00	1 / 430
prostate	0%	0	0 / 245	1%	0.01	4 / 502
bladder	0%	0	0 / 21	1%	0.01	4 / 504
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0050832	Biological process	defense response to fungus
GO_0045087	Biological process	innate immune response
GO_0019731	Biological process	antibacterial humoral response
GO_0050829	Biological process	defense response to Gram-negative bacterium
GO_0019730	Biological process	antimicrobial humoral response
GO_0051673	Biological process	disruption of plasma membrane integrity in another organism
GO_0031640	Biological process	killing of cells of another organism
GO_0050830	Biological process	defense response to Gram-positive bacterium
GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0061844	Biological process	antimicrobial humoral immune response mediated by antimicrobial peptide
GO_0002227	Biological process	innate immune response in mucosa
GO_0019732	Biological process	antifungal humoral response
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0035580	Cellular component	specific granule lumen
GO_0005796	Cellular component	Golgi lumen
GO_0042582	Cellular component	azurophil granule
GO_0030133	Cellular component	transport vesicle
GO_0042803	Molecular function	protein homodimerization activity

Gene name	DEFA4
Protein name	Defensin alpha 4 (Corticostatin HP-4) (HNP-4) (HP-4) (Neutrophil defensin 4)
Synonyms	DEF4
Description	FUNCTION: Host-defense peptide that has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi . Exhibits antimicrobial activity against Gram-negative E.coli and E.aerogenes and Gram-positive S.faecalis, S.aureus and B.cereus and the yeast C.albicans (in vitro) . Interacts with pathogenic surface proteins and toxins, such as HIV-1 surface protein gp120 and B.anthracis anthrax lethal factor lef . Protects blood cells against infection with HIV-1 (in vitro) . Inhibits enzymatic activity of B.anthracis lef/anthrax lethal factor (in vitro) . Inhibits corticotropin (ACTH)-stimulated corticosterone production (in vitro) . .
Accessions	P12838 ENST00000642522.2 ENST00000297435.3

DEFA4 report