DDX4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DDX4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DDX4 at tissue level.

III. Associated gene sets

GO_0007283Biological processspermatogenesis
GO_0141006Biological processpiRNA-mediated retrotransposon silencing by heterochromatin formation
GO_0007276Biological processgamete generation
GO_0141007Biological processsiRNA-mediated retrotransposon silencing by heterochromatin formation
GO_0007141Biological processmale meiosis I
GO_0030317Biological processflagellated sperm motility
GO_0007281Biological processgerm cell development
GO_0030154Biological processcell differentiation
GO_0007140Biological processmale meiotic nuclear division
GO_0034587Biological processpiRNA processing
GO_0071547Cellular componentpiP-body
GO_0043186Cellular componentP granule
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0071546Cellular componentpi-body
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003724Molecular functionRNA helicase activity
GO_0003729Molecular functionmRNA binding
GO_0140693Molecular functionmolecular condensate scaffold activity
GO_0005524Molecular functionATP binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameDDX4
Protein nameProbable ATP-dependent RNA helicase DDX4 (EC 3.6.4.13) (DEAD box protein 4) (Vasa homolog)
DEAD-box helicase 4
RNA helicase (EC 3.6.4.13)
SynonymsVASA
DescriptionFUNCTION: ATP-dependent RNA helicase required during spermatogenesis . Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (By similarity). Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle (By similarity). Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs (By similarity). .

AccessionsENST00000506848.5
Q9NQI0
ENST00000353507.9 [Q9NQI0-2]
D6RBL3
ENST00000511853.1 [Q9NQI0-3]
ENST00000511491.5
D6RIB2
H0Y960
H0YBW0
ENST00000505374.6 [Q9NQI0-1]
ENST00000503129.5
D6RCM4
ENST00000514679.5
ENST00000507645.5
ENST00000354991.9 [Q9NQI0-2]
ENST00000514278.6 [Q9NQI0-4]
ENST00000515709.5
ENST00000506511.5
D6RAF5
D6RAT7