DDI2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0072711Biological processcellular response to hydroxyurea
GO_0016485Biological processprotein processing
GO_0031647Biological processregulation of protein stability
GO_0097752Biological processregulation of DNA stability
GO_0010498Biological processproteasomal protein catabolic process
GO_0005694Cellular componentchromosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0004190Molecular functionaspartic-type endopeptidase activity
GO_0043130Molecular functionubiquitin binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDDI2
Protein nameProtein DDI1 homolog 2 (EC 3.4.23.-)
DNA damage inducible 1 homolog 2
Synonyms
DescriptionFUNCTION: Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane . Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1 . Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity . .

AccessionsA0AA34QVL7
ENST00000320153.10
H0YII4
H0YI90
ENST00000711099.1
Q5TDH0
ENST00000480945.6 [Q5TDH0-1]
A0AA34QVV2
ENST00000711098.1
ENST00000483899.1