Name | Number of supported studies | Average coverage | |
---|---|---|---|
adipocyte | 8 studies | 25% ± 5% | |
endothelial cell | 6 studies | 26% ± 15% | |
epithelial cell | 5 studies | 34% ± 13% | |
ciliated cell | 5 studies | 27% ± 10% | |
macrophage | 5 studies | 22% ± 7% | |
hepatocyte | 4 studies | 42% ± 9% | |
club cell | 4 studies | 23% ± 10% | |
erythrocyte | 4 studies | 41% ± 12% | |
oligodendrocyte | 4 studies | 23% ± 5% | |
myeloid cell | 3 studies | 19% ± 5% | |
GABAergic neuron | 3 studies | 34% ± 7% | |
glutamatergic neuron | 3 studies | 42% ± 4% | |
alveolar macrophage | 3 studies | 22% ± 6% | |
basal cell | 3 studies | 34% ± 15% | |
goblet cell | 3 studies | 30% ± 19% | |
transit amplifying cell | 3 studies | 26% ± 15% | |
erythroblast | 3 studies | 31% ± 6% | |
astrocyte | 3 studies | 23% ± 3% | |
microglial cell | 3 studies | 25% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
bladder | 100% | 3580.10 | 21 / 21 | 100% | 16.04 | 504 / 504 |
breast | 100% | 4388.47 | 459 / 459 | 100% | 22.71 | 1118 / 1118 |
esophagus | 100% | 3710.31 | 1445 / 1445 | 100% | 18.16 | 183 / 183 |
prostate | 100% | 4181.08 | 245 / 245 | 100% | 28.70 | 501 / 502 |
lung | 100% | 3649.65 | 578 / 578 | 100% | 14.53 | 1150 / 1155 |
liver | 100% | 4104.91 | 226 / 226 | 99% | 12.43 | 403 / 406 |
intestine | 100% | 2629.57 | 966 / 966 | 99% | 13.41 | 522 / 527 |
thymus | 100% | 2414.14 | 652 / 653 | 99% | 10.69 | 600 / 605 |
uterus | 100% | 4031.58 | 170 / 170 | 99% | 15.55 | 454 / 459 |
stomach | 100% | 1941.63 | 358 / 359 | 98% | 13.30 | 281 / 286 |
skin | 100% | 4299.60 | 1809 / 1809 | 97% | 12.85 | 458 / 472 |
pancreas | 99% | 1795.89 | 324 / 328 | 98% | 12.09 | 174 / 178 |
kidney | 100% | 2182.48 | 89 / 89 | 95% | 9.34 | 857 / 901 |
ovary | 100% | 2465.74 | 180 / 180 | 94% | 8.02 | 406 / 430 |
brain | 94% | 1431.04 | 2472 / 2642 | 96% | 6.60 | 674 / 705 |
adrenal gland | 100% | 2593.98 | 258 / 258 | 69% | 3.61 | 158 / 230 |
adipose | 100% | 4366.22 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 14.30 | 29 / 29 |
muscle | 100% | 7070.85 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2905.38 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 18.83 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 8.71 | 1 / 1 |
blood vessel | 100% | 2077.67 | 1334 / 1335 | 0% | 0 | 0 / 0 |
heart | 96% | 1765.58 | 825 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 91% | 9.89 | 73 / 80 |
peripheral blood | 53% | 1286.77 | 489 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0072711 | Biological process | cellular response to hydroxyurea |
GO_0016485 | Biological process | protein processing |
GO_0031647 | Biological process | regulation of protein stability |
GO_0097752 | Biological process | regulation of DNA stability |
GO_0010498 | Biological process | proteasomal protein catabolic process |
GO_0005694 | Cellular component | chromosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0004190 | Molecular function | aspartic-type endopeptidase activity |
GO_0043130 | Molecular function | ubiquitin binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0005515 | Molecular function | protein binding |
Gene name | DDI2 |
Protein name | Protein DDI1 homolog 2 (EC 3.4.23.-) DNA damage inducible 1 homolog 2 |
Synonyms | |
Description | FUNCTION: Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane . Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1 . Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity . . |
Accessions | A0AA34QVL7 ENST00000320153.10 H0YII4 H0YI90 ENST00000711099.1 Q5TDH0 ENST00000480945.6 [Q5TDH0-1] A0AA34QVV2 ENST00000711098.1 ENST00000483899.1 |