DDI1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DDI1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DDI1 at tissue level.

III. Associated gene sets

GO_0072711Biological processcellular response to hydroxyurea
GO_0031647Biological processregulation of protein stability
GO_0097752Biological processregulation of DNA stability
GO_0010498Biological processproteasomal protein catabolic process
GO_0004190Molecular functionaspartic-type endopeptidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDDI1
Protein nameProtein DDI1 homolog 1 (EC 3.4.23.-)
Synonyms
DescriptionFUNCTION: Probable aspartic protease (Probable). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI2, for cellular survival following replication stress. Together or redudantly with DDI2, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity . .

AccessionsENST00000302259.5
Q8WTU0