DCTN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1905515Biological processnon-motile cilium assembly
GO_0099558Biological processmaintenance of synapse structure
GO_0000278Biological processmitotic cell cycle
GO_0061744Biological processmotor behavior
GO_0021517Biological processventral spinal cord development
GO_0000132Biological processestablishment of mitotic spindle orientation
GO_0010457Biological processcentriole-centriole cohesion
GO_0051301Biological processcell division
GO_1904398Biological processpositive regulation of neuromuscular junction development
GO_1990535Biological processneuron projection maintenance
GO_0050905Biological processneuromuscular process
GO_0031116Biological processpositive regulation of microtubule polymerization
GO_0007528Biological processneuromuscular junction development
GO_0032402Biological processmelanosome transport
GO_0098930Biological processaxonal transport
GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0070050Biological processneuron cellular homeostasis
GO_0090063Biological processpositive regulation of microtubule nucleation
GO_0051081Biological processnuclear membrane disassembly
GO_0007097Biological processnuclear migration
GO_0034454Biological processmicrotubule anchoring at centrosome
GO_0060236Biological processregulation of mitotic spindle organization
GO_0007399Biological processnervous system development
GO_0099738Cellular componentcell cortex region
GO_0005874Cellular componentmicrotubule
GO_0000922Cellular componentspindle pole
GO_0072686Cellular componentmitotic spindle
GO_0016020Cellular componentmembrane
GO_0005813Cellular componentcentrosome
GO_0000776Cellular componentkinetochore
GO_0035371Cellular componentmicrotubule plus-end
GO_0043025Cellular componentneuronal cell body
GO_0005635Cellular componentnuclear envelope
GO_0043005Cellular componentneuron projection
GO_0031252Cellular componentcell leading edge
GO_0045171Cellular componentintercellular bridge
GO_0005814Cellular componentcentriole
GO_0030904Cellular componentretromer complex
GO_0120103Cellular componentcentriolar subdistal appendage
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0036064Cellular componentciliary basal body
GO_0005875Cellular componentmicrotubule associated complex
GO_0030286Cellular componentdynein complex
GO_0005819Cellular componentspindle
GO_0015631Molecular functiontubulin binding
GO_0019901Molecular functionprotein kinase binding
GO_0008017Molecular functionmicrotubule binding
GO_0048156Molecular functiontau protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDCTN1
Protein nameDynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued)
Alternative protein DCTN1
Dynactin subunit 1
SynonymsDKFZp686E0752
DescriptionFUNCTION: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule . Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon . Plays a role in metaphase spindle orientation . Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole . Plays a role in primary cilia formation . .

AccessionsENST00000628224.3 [Q14203-1]
ENST00000409567.7 [Q14203-4]
ENST00000434055.5
ENST00000409438.5 [Q14203-5]
ENST00000361874.8
ENST00000628224
ENST00000394003.7 [Q14203-6]
C9JZA4
Q14203
C9JUI8
ENST00000417090.1
ENST00000454119.5
C9JTE5
L8EA71
C9JJN7
ENST00000437375.1
A0A7P0Z4C3
ENST00000440727.1
ENST00000409240.5 [Q14203-3]
C9JKG6
E7EX90
ENST00000449655.1
A0A804CDA6
ENST00000458655.5
Q6AWB1
ENST00000413111.5
C9J1B7
ENST00000633691.1 [Q14203-2]
ENST00000421392.1
C9JJD0
ENST00000680606.1
ENST00000409868.5
E9PCY0