Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 9 studies | 25% ± 10% | |
neuron | 5 studies | 28% ± 13% | |
epithelial cell | 5 studies | 28% ± 10% | |
plasmacytoid dendritic cell | 5 studies | 19% ± 4% | |
non-classical monocyte | 4 studies | 19% ± 4% | |
retinal ganglion cell | 4 studies | 59% ± 23% | |
CD16-positive, CD56-dim natural killer cell, human | 4 studies | 16% ± 1% | |
ciliated cell | 4 studies | 21% ± 6% | |
fibroblast | 4 studies | 20% ± 4% | |
retina horizontal cell | 3 studies | 26% ± 4% | |
abnormal cell | 3 studies | 22% ± 2% | |
GABAergic neuron | 3 studies | 36% ± 13% | |
glutamatergic neuron | 3 studies | 48% ± 18% | |
dendritic cell | 3 studies | 26% ± 5% | |
gamma-delta T cell | 3 studies | 21% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 12076.07 | 1445 / 1445 | 100% | 45.31 | 183 / 183 |
brain | 100% | 23268.29 | 2641 / 2642 | 100% | 71.21 | 703 / 705 |
stomach | 100% | 8882.27 | 359 / 359 | 100% | 32.62 | 285 / 286 |
breast | 100% | 10476.06 | 459 / 459 | 99% | 48.56 | 1112 / 1118 |
ovary | 100% | 10979.09 | 180 / 180 | 99% | 33.39 | 427 / 430 |
thymus | 100% | 9858.20 | 653 / 653 | 99% | 34.70 | 600 / 605 |
skin | 100% | 12507.13 | 1808 / 1809 | 99% | 56.95 | 468 / 472 |
intestine | 100% | 11529.15 | 966 / 966 | 99% | 33.53 | 522 / 527 |
lung | 100% | 10424.13 | 577 / 578 | 99% | 39.41 | 1146 / 1155 |
prostate | 100% | 9775.40 | 244 / 245 | 99% | 38.37 | 498 / 502 |
uterus | 100% | 13347.15 | 170 / 170 | 99% | 38.07 | 453 / 459 |
bladder | 100% | 12266.81 | 21 / 21 | 98% | 32.40 | 492 / 504 |
kidney | 100% | 7734.52 | 89 / 89 | 97% | 36.31 | 872 / 901 |
pancreas | 96% | 4762.59 | 315 / 328 | 98% | 34.79 | 175 / 178 |
adrenal gland | 100% | 10980.05 | 258 / 258 | 94% | 54.91 | 217 / 230 |
liver | 79% | 3126.54 | 179 / 226 | 87% | 18.01 | 353 / 406 |
adipose | 100% | 10765.01 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 14432.03 | 1335 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 61.72 | 80 / 80 |
muscle | 100% | 11248.12 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 8687.46 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 41.07 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 9.95 | 1 / 1 |
heart | 98% | 11480.08 | 847 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 97% | 30.00 | 28 / 29 |
peripheral blood | 89% | 5689.12 | 831 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_1905515 | Biological process | non-motile cilium assembly |
GO_0099558 | Biological process | maintenance of synapse structure |
GO_0000278 | Biological process | mitotic cell cycle |
GO_0061744 | Biological process | motor behavior |
GO_0021517 | Biological process | ventral spinal cord development |
GO_0000132 | Biological process | establishment of mitotic spindle orientation |
GO_0010457 | Biological process | centriole-centriole cohesion |
GO_0051301 | Biological process | cell division |
GO_1904398 | Biological process | positive regulation of neuromuscular junction development |
GO_1990535 | Biological process | neuron projection maintenance |
GO_0050905 | Biological process | neuromuscular process |
GO_0031116 | Biological process | positive regulation of microtubule polymerization |
GO_0007528 | Biological process | neuromuscular junction development |
GO_0032402 | Biological process | melanosome transport |
GO_0098930 | Biological process | axonal transport |
GO_0042147 | Biological process | retrograde transport, endosome to Golgi |
GO_0070050 | Biological process | neuron cellular homeostasis |
GO_0090063 | Biological process | positive regulation of microtubule nucleation |
GO_0051081 | Biological process | nuclear membrane disassembly |
GO_0007097 | Biological process | nuclear migration |
GO_0034454 | Biological process | microtubule anchoring at centrosome |
GO_0060236 | Biological process | regulation of mitotic spindle organization |
GO_0007399 | Biological process | nervous system development |
GO_0099738 | Cellular component | cell cortex region |
GO_0005874 | Cellular component | microtubule |
GO_0000922 | Cellular component | spindle pole |
GO_0072686 | Cellular component | mitotic spindle |
GO_0016020 | Cellular component | membrane |
GO_0005813 | Cellular component | centrosome |
GO_0000776 | Cellular component | kinetochore |
GO_0035371 | Cellular component | microtubule plus-end |
GO_0043025 | Cellular component | neuronal cell body |
GO_0005635 | Cellular component | nuclear envelope |
GO_0043005 | Cellular component | neuron projection |
GO_0031252 | Cellular component | cell leading edge |
GO_0045171 | Cellular component | intercellular bridge |
GO_0005814 | Cellular component | centriole |
GO_0030904 | Cellular component | retromer complex |
GO_0120103 | Cellular component | centriolar subdistal appendage |
GO_0005829 | Cellular component | cytosol |
GO_0005938 | Cellular component | cell cortex |
GO_0015630 | Cellular component | microtubule cytoskeleton |
GO_0005737 | Cellular component | cytoplasm |
GO_0030424 | Cellular component | axon |
GO_0036064 | Cellular component | ciliary basal body |
GO_0005875 | Cellular component | microtubule associated complex |
GO_0030286 | Cellular component | dynein complex |
GO_0005819 | Cellular component | spindle |
GO_0015631 | Molecular function | tubulin binding |
GO_0019901 | Molecular function | protein kinase binding |
GO_0008017 | Molecular function | microtubule binding |
GO_0048156 | Molecular function | tau protein binding |
GO_0005515 | Molecular function | protein binding |
Gene name | DCTN1 |
Protein name | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) Alternative protein DCTN1 Dynactin subunit 1 |
Synonyms | DKFZp686E0752 |
Description | FUNCTION: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule . Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon . Plays a role in metaphase spindle orientation . Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole . Plays a role in primary cilia formation . . |
Accessions | ENST00000628224.3 [Q14203-1] ENST00000409567.7 [Q14203-4] ENST00000434055.5 ENST00000409438.5 [Q14203-5] ENST00000361874.8 ENST00000628224 ENST00000394003.7 [Q14203-6] C9JZA4 Q14203 C9JUI8 ENST00000417090.1 ENST00000454119.5 C9JTE5 L8EA71 C9JJN7 ENST00000437375.1 A0A7P0Z4C3 ENST00000440727.1 ENST00000409240.5 [Q14203-3] C9JKG6 E7EX90 ENST00000449655.1 A0A804CDA6 ENST00000458655.5 Q6AWB1 ENST00000413111.5 C9J1B7 ENST00000633691.1 [Q14203-2] ENST00000421392.1 C9JJD0 ENST00000680606.1 ENST00000409868.5 E9PCY0 |