DCTD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006220Biological processpyrimidine nucleotide metabolic process
GO_0009165Biological processnucleotide biosynthetic process
GO_0043174Biological processnucleoside salvage
GO_0009972Biological processcytidine deamination
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0070694Molecular functiondeoxyribonucleoside 5'-monophosphate N-glycosidase activity
GO_0004132Molecular functiondCMP deaminase activity
GO_0005515Molecular functionprotein binding
GO_0042802Molecular functionidentical protein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameDCTD
Protein namedCMP deaminase
Deoxycytidylate deaminase (EC 3.5.4.12) (dCMP deaminase)
Synonyms
DescriptionFUNCTION: Catalyzes the deamination of dCMP to dUMP, providing the nucleoside monophosphate substrate for the thymidylate synthase/TYMS . Also, part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate) . Catalyzes the first step in that pathway, the deamination of 5-hydroxymethyl-dCMP (hmdCMP) . .

AccessionsP32321
ENST00000510307.5
ENST00000507543.5
ENST00000513348.5
ENST00000514754.5
ENST00000503820.5
ENST00000507631.5
ENST00000438320.7 [P32321-1]
D6R9S0
ENST00000509218.5
D6RAR9
D6RBJ9
D6RJA9
ENST00000512766.5
D6RBN2
D6RD72
D6RAD7
ENST00000503988.1
D6RC36
D6R9P0
ENST00000509757.5
ENST00000500813.6
D6RIG3
ENST00000510370.5 [P32321-1]
ENST00000357067.7 [P32321-2]
ENST00000503182.5
ENST00000508994.1