DCSTAMP report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DCSTAMP at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DCSTAMP at tissue level.

III. Associated gene sets

GO_0071560Biological processcellular response to transforming growth factor beta stimulus
GO_0030316Biological processosteoclast differentiation
GO_0061025Biological processmembrane fusion
GO_0071353Biological processcellular response to interleukin-4
GO_0045657Biological processpositive regulation of monocyte differentiation
GO_0072675Biological processosteoclast fusion
GO_0034241Biological processpositive regulation of macrophage fusion
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0036006Biological processcellular response to macrophage colony-stimulating factor stimulus
GO_0043011Biological processmyeloid dendritic cell differentiation
GO_0045780Biological processpositive regulation of bone resorption
GO_0030308Biological processnegative regulation of cell growth
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0033116Cellular componentendoplasmic reticulum-Golgi intermediate compartment membrane
GO_0009986Cellular componentcell surface
GO_0010008Cellular componentendosome membrane
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDCSTAMP
Protein nameDendritic cell-specific transmembrane protein (DC-STAMP) (hDC-STAMP) (Dendrocyte-expressed seven transmembrane protein) (IL-four-induced protein) (FIND) (Transmembrane 7 superfamily member 4)
SynonymsTM7SF4
DescriptionFUNCTION: Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.

AccessionsENST00000517991.5 [Q9H295-2]
ENST00000297581.2 [Q9H295-1]
Q9H295
ENST00000622554.1 [Q9H295-2]