DCAF15 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DCAF15 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DCAF15 at tissue level.

III. Associated gene sets

GO_0002376Biological processimmune system process
GO_0016567Biological processprotein ubiquitination
GO_0000209Biological processprotein polyubiquitination
GO_0032814Biological processregulation of natural killer cell activation
GO_0080008Cellular componentCul4-RING E3 ubiquitin ligase complex
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0036094Molecular functionsmall molecule binding

IV. Literature review

[source]
Gene nameDCAF15
Protein nameDDB1 and CUL4 associated factor 15
DDB1- and CUL4-associated factor 15
SynonymsC19orf72
DescriptionFUNCTION: Substrate-recognition component of the DCX(DCAF15) complex, a cullin-4-RING E3 ubiquitin-protein ligase complex that mediates ubiquitination and degradation of target proteins . The DCX(DCAF15) complex acts as a regulator of the natural killer (NK) cells effector functions, possibly by mediating ubiquitination and degradation of cohesin subunits SMC1A and SMC3 . May play a role in the activation of antigen-presenting cells (APC) and their interaction with NK cells . .; FUNCTION: Binding of aryl sulfonamide anticancer drugs, such as indisulam (E7070) or E7820, change the substrate specificity of the DCX(DCAF15) complex, leading to promote ubiquitination and degradation of splicing factor RBM39 . RBM39 degradation results in splicing defects and death in cancer cell lines . Aryl sulfonamide anticancer drugs change the substrate specificity of DCAF15 by acting as a molecular glue that promotes binding between DCAF15 and weak affinity interactor RBM39 . Aryl sulfonamide anticancer drugs also promote ubiquitination and degradation of RBM23 and PRPF39 . .

AccessionsK7ENG0
ENST00000672437.1
Q66K64
ENST00000591802.1
ENST00000254337.11
K7ELE9
K7ERN0
ENST00000587307.1
ENST00000585468.1