I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 3 studies | 20% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 3 studies | 20% ± 2% |
Insufficient scRNA-seq data for expression of DARS2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 699.70 | 1444 / 1445 | 100% | 26.59 | 183 / 183 |
| ovary | 100% | 532.32 | 180 / 180 | 100% | 18.30 | 429 / 430 |
| stomach | 100% | 820.29 | 359 / 359 | 100% | 22.39 | 285 / 286 |
| breast | 100% | 869.63 | 459 / 459 | 99% | 23.16 | 1111 / 1118 |
| lung | 100% | 734.81 | 576 / 578 | 100% | 19.03 | 1151 / 1155 |
| intestine | 100% | 899.68 | 966 / 966 | 99% | 19.86 | 522 / 527 |
| uterus | 100% | 604.04 | 170 / 170 | 99% | 17.85 | 453 / 459 |
| bladder | 100% | 707.29 | 21 / 21 | 99% | 17.25 | 497 / 504 |
| skin | 100% | 1258.04 | 1807 / 1809 | 98% | 23.23 | 461 / 472 |
| pancreas | 99% | 539.17 | 325 / 328 | 98% | 10.85 | 174 / 178 |
| prostate | 100% | 578.49 | 245 / 245 | 95% | 11.12 | 478 / 502 |
| kidney | 100% | 1022.09 | 89 / 89 | 94% | 11.50 | 846 / 901 |
| liver | 100% | 654.36 | 225 / 226 | 94% | 13.07 | 381 / 406 |
| brain | 97% | 371.95 | 2572 / 2642 | 95% | 8.66 | 667 / 705 |
| thymus | 100% | 774.54 | 653 / 653 | 91% | 7.61 | 553 / 605 |
| adrenal gland | 100% | 1677.71 | 258 / 258 | 74% | 6.51 | 170 / 230 |
| adipose | 100% | 862.22 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 18.13 | 29 / 29 |
| spleen | 100% | 845.73 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 17.55 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 6.95 | 1 / 1 |
| blood vessel | 100% | 543.18 | 1332 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 99% | 562.78 | 797 / 803 | 0% | 0 | 0 / 0 |
| heart | 96% | 714.09 | 826 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 89% | 9.34 | 71 / 80 |
| peripheral blood | 79% | 1073.90 | 737 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0043039 | Biological process | tRNA aminoacylation |
| GO_0006422 | Biological process | aspartyl-tRNA aminoacylation |
| GO_0070145 | Biological process | mitochondrial asparaginyl-tRNA aminoacylation |
| GO_0031966 | Cellular component | mitochondrial membrane |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005759 | Cellular component | mitochondrial matrix |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0050560 | Molecular function | aspartate-tRNA(Asn) ligase activity |
| GO_0000049 | Molecular function | tRNA binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0004815 | Molecular function | aspartate-tRNA ligase activity |
| GO_0005524 | Molecular function | ATP binding |
| Gene name | DARS2 |
| Protein name | Aspartyl-tRNA synthetase 2, mitochondrial Aspartate--tRNA ligase, mitochondrial (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) |
| Synonyms | |
| Description | FUNCTION: Catalyzes the attachment of aspartate to tRNA(Asp) in a two-step reaction: aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp). . |
| Accessions | A0A3B3IT89 ENST00000649067.1 A0A3B3IT01 ENST00000648960.1 ENST00000648458.1 ENST00000649689.2 ENST00000648807.1 ENST00000647645.1 Q6PI48 A0A3B3ITS3 A0A3B3IS01 A0A3B3ISK7 A0A3B3IS54 ENST00000649106.1 ENST00000648271.1 A0A3B3ITK9 ENST00000647788.1 ENST00000647730.1 ENST00000471476.2 |
