DAGLB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006640Biological processmonoacylglycerol biosynthetic process
GO_0022008Biological processneurogenesis
GO_0010898Biological processpositive regulation of triglyceride catabolic process
GO_0019369Biological processarachidonic acid metabolic process
GO_0050727Biological processregulation of inflammatory response
GO_0046340Biological processdiacylglycerol catabolic process
GO_1901696Biological processcannabinoid biosynthetic process
GO_0001516Biological processprostaglandin biosynthetic process
GO_0007405Biological processneuroblast proliferation
GO_0005654Cellular componentnucleoplasm
GO_0005886Cellular componentplasma membrane
GO_0005765Cellular componentlysosomal membrane
GO_0004806Molecular functiontriglyceride lipase activity
GO_0047372Molecular functionacylglycerol lipase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0016298Molecular functionlipase activity

IV. Literature review

[source]
Gene nameDAGLB
Protein nameDiacylglycerol lipase beta
Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.116) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta)
sn-1-specific diacylglycerol lipase (EC 3.1.1.116)
Synonyms
DescriptionFUNCTION: Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production . Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids . Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Functions also as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages (By similarity). .

AccessionsF8WBN0
Q8NCG7
ENST00000436575.5
E7ET49
C9JA85
ENST00000432248.1
ENST00000454738.5
ENST00000297056.11 [Q8NCG7-1]
ENST00000425398.6 [Q8NCG7-4]