DAGLA report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DAGLA at tissue level.

III. Associated gene sets

GO_0006640Biological processmonoacylglycerol biosynthetic process
GO_0098921Biological processretrograde trans-synaptic signaling by endocannabinoid
GO_0150077Biological processregulation of neuroinflammatory response
GO_0007216Biological processG protein-coupled glutamate receptor signaling pathway
GO_0046340Biological processdiacylglycerol catabolic process
GO_1901696Biological processcannabinoid biosynthetic process
GO_0019369Biological processarachidonic acid metabolic process
GO_0007405Biological processneuroblast proliferation
GO_0098839Cellular componentpostsynaptic density membrane
GO_0005886Cellular componentplasma membrane
GO_0031901Cellular componentearly endosome membrane
GO_0043196Cellular componentvaricosity
GO_0032591Cellular componentdendritic spine membrane
GO_0005737Cellular componentcytoplasm
GO_0045211Cellular componentpostsynaptic membrane
GO_0032590Cellular componentdendrite membrane
GO_0004465Molecular functionlipoprotein lipase activity
GO_0046872Molecular functionmetal ion binding
GO_0047372Molecular functionacylglycerol lipase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDAGLA
Protein nameDiacylglycerol lipase-alpha (DAGL-alpha) (DGL-alpha) (EC 3.1.1.116) (Neural stem cell-derived dendrite regulator) (Sn1-specific diacylglycerol lipase alpha)
Diacylglycerol lipase alpha
SynonymsKIAA0659
NSDDR
C11orf11
DescriptionFUNCTION: Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) . Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG . Has negligible activity against other lipids including monoacylglycerols and phospholipids . Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Regulates also neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation (By similarity). .

AccessionsENST00000540717.1
ENST00000257215.10
F5GY58
Q9Y4D2