DACH2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046545Biological processdevelopment of primary female sexual characteristics
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene nameDACH2
Protein nameDachshund family transcription factor 2
DACH2 protein
Dachshund homolog 2 (Dach2)
Synonyms
DescriptionFUNCTION: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity). Probably binds to DNA via its DACHbox-N domain. .

AccessionsD6REJ4
ENST00000373125.9 [Q96NX9-1]
ENST00000373131.5 [Q96NX9-2]
Q1RMF5
ENST00000484479.1
ENST00000510272.5 [Q96NX9-3]
ENST00000506327.6
ENST00000508860.5 [Q96NX9-4]
D6RFG7
ENST00000461604.6
Q96NX9
H0Y912