I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| hepatocyte | 4 studies | 53% ± 23% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| hepatocyte | 4 studies | 53% ± 23% |
Insufficient scRNA-seq data for expression of CYP8B1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 33648.21 | 226 / 226 | 85% | 187.06 | 347 / 406 |
| kidney | 100% | 800.47 | 89 / 89 | 68% | 4.79 | 612 / 901 |
| bladder | 90% | 28.95 | 19 / 21 | 14% | 0.32 | 73 / 504 |
| thymus | 99% | 78.04 | 649 / 653 | 0% | 0.01 | 2 / 605 |
| lung | 93% | 43.71 | 540 / 578 | 6% | 0.14 | 71 / 1155 |
| breast | 90% | 41.80 | 414 / 459 | 6% | 0.24 | 69 / 1118 |
| adipose | 96% | 71.05 | 1156 / 1204 | 0% | 0 | 0 / 0 |
| esophagus | 90% | 39.16 | 1296 / 1445 | 2% | 0.04 | 4 / 183 |
| blood vessel | 83% | 32.21 | 1108 / 1335 | 0% | 0 | 0 / 0 |
| adrenal gland | 79% | 18.28 | 204 / 258 | 0% | 0 | 0 / 230 |
| uterus | 69% | 16.68 | 118 / 170 | 9% | 0.26 | 43 / 459 |
| prostate | 75% | 18.13 | 184 / 245 | 1% | 0.02 | 4 / 502 |
| intestine | 75% | 21.03 | 720 / 966 | 1% | 0.59 | 4 / 527 |
| skin | 60% | 19.35 | 1090 / 1809 | 0% | 0.01 | 2 / 472 |
| spleen | 56% | 49.83 | 136 / 241 | 0% | 0 | 0 / 0 |
| stomach | 54% | 12.12 | 195 / 359 | 0% | 0.00 | 1 / 286 |
| ovary | 38% | 7.90 | 69 / 180 | 13% | 0.24 | 58 / 430 |
| heart | 50% | 14.62 | 429 / 861 | 0% | 0 | 0 / 0 |
| muscle | 35% | 11.11 | 284 / 803 | 0% | 0 | 0 / 0 |
| brain | 32% | 4.98 | 841 / 2642 | 0% | 0.00 | 1 / 705 |
| pancreas | 22% | 3.35 | 71 / 328 | 3% | 0.22 | 6 / 178 |
| peripheral blood | 12% | 7.47 | 110 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0038183 | Biological process | bile acid signaling pathway |
| GO_0070723 | Biological process | response to cholesterol |
| GO_0031667 | Biological process | response to nutrient levels |
| GO_0006699 | Biological process | bile acid biosynthetic process |
| GO_0045797 | Biological process | positive regulation of intestinal cholesterol absorption |
| GO_0016125 | Biological process | sterol metabolic process |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0019825 | Molecular function | oxygen binding |
| GO_0008397 | Molecular function | sterol 12-alpha-hydroxylase activity |
| GO_0033778 | Molecular function | 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity |
| GO_0033779 | Molecular function | 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activity |
| GO_0005506 | Molecular function | iron ion binding |
| GO_0020037 | Molecular function | heme binding |
| Gene name | CYP8B1 |
| Protein name | Cytochrome P450 family 8 subfamily B member 1 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (EC 1.14.14.139) (7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase) (CYPVIIIB1) (Cytochrome P450 8B1) (Sterol 12-alpha-hydroxylase) |
| Synonyms | CYP12 |
| Description | FUNCTION: A cytochrome P450 monooxygenase involved in primary bile acid biosynthesis. Catalyzes the 12alpha-hydroxylation of 7alpha-hydroxy-4-cholesten-3-one, an intermediate metabolite in cholic acid biosynthesis . Controls biliary balance of cholic acid and chenodeoxycholic acid, ultimately regulating the intestinal absorption of dietary lipids (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH--hemoprotein reductase) (By similarity). . |
| Accessions | C9JFR9 ENST00000316161.6 Q9UNU6 ENST00000437102.1 |
