CYP4F22 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CYP4F22 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYP4F22 at tissue level.

III. Associated gene sets

GO_0006690Biological processicosanoid metabolic process
GO_0046513Biological processceramide biosynthetic process
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0004497Molecular functionmonooxygenase activity
GO_0005506Molecular functioniron ion binding
GO_0020037Molecular functionheme binding
GO_0005515Molecular functionprotein binding
GO_0016705Molecular functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

IV. Literature review

[source]
Gene nameCYP4F22
Protein nameCytochrome P450 4F22
Ultra-long-chain fatty acid omega-hydroxylase (EC 1.14.14.177) (Cytochrome P450 4F22)
Synonyms
DescriptionFUNCTION: A cytochrome P450 monooxygenase involved in epidermal ceramide biosynthesis. Hydroxylates the terminal carbon (omega-hydroxylation) of ultra-long-chain fatty acyls (C28-C36) prior to ceramide synthesis . Contributes to the synthesis of three classes of omega-hydroxy-ultra-long chain fatty acylceramides having sphingosine, 6-hydroxysphingosine and phytosphingosine bases, all major lipid components that underlie the permeability barrier of the stratum corneum . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) . .

AccessionsA0A1B1SMS2
ENST00000269703.8
Q6NT55
ENST00000601005.2