I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| enterocyte | 3 studies | 23% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| enterocyte | 3 studies | 23% ± 4% |
Insufficient scRNA-seq data for expression of CYP4F12 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 4373.57 | 226 / 226 | 90% | 16.90 | 364 / 406 |
| intestine | 96% | 3285.26 | 929 / 966 | 91% | 13.09 | 479 / 527 |
| stomach | 81% | 1125.08 | 292 / 359 | 83% | 11.94 | 237 / 286 |
| bladder | 90% | 3175.62 | 19 / 21 | 73% | 19.55 | 369 / 504 |
| esophagus | 79% | 1571.73 | 1142 / 1445 | 62% | 6.21 | 113 / 183 |
| uterus | 81% | 1040.38 | 137 / 170 | 56% | 8.22 | 257 / 459 |
| prostate | 91% | 1757.41 | 223 / 245 | 42% | 2.45 | 211 / 502 |
| breast | 86% | 844.66 | 395 / 459 | 19% | 1.15 | 214 / 1118 |
| ureter | 0% | 0 | 0 / 0 | 100% | 2.64 | 1 / 1 |
| adipose | 88% | 941.77 | 1059 / 1204 | 0% | 0 | 0 / 0 |
| pancreas | 3% | 14.03 | 9 / 328 | 81% | 10.78 | 145 / 178 |
| kidney | 60% | 416.99 | 53 / 89 | 20% | 1.09 | 184 / 901 |
| lung | 45% | 266.68 | 259 / 578 | 31% | 2.22 | 361 / 1155 |
| skin | 72% | 3163.23 | 1301 / 1809 | 3% | 0.10 | 15 / 472 |
| ovary | 62% | 574.81 | 112 / 180 | 6% | 0.27 | 26 / 430 |
| spleen | 66% | 385.85 | 158 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 58% | 10.02 | 26 / 45 |
| thymus | 42% | 230.64 | 273 / 653 | 4% | 0.38 | 24 / 605 |
| adrenal gland | 41% | 233.33 | 105 / 258 | 4% | 0.19 | 10 / 230 |
| heart | 34% | 172.01 | 291 / 861 | 0% | 0 | 0 / 0 |
| brain | 2% | 12.97 | 59 / 2642 | 19% | 1.45 | 135 / 705 |
| blood vessel | 17% | 102.50 | 228 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 4% | 20.35 | 37 / 929 | 0% | 0 | 0 / 0 |
| muscle | 0% | 2.06 | 4 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006805 | Biological process | xenobiotic metabolic process |
| GO_0003091 | Biological process | renal water homeostasis |
| GO_0055078 | Biological process | sodium ion homeostasis |
| GO_0000038 | Biological process | very long-chain fatty acid metabolic process |
| GO_0042360 | Biological process | vitamin E metabolic process |
| GO_0042361 | Biological process | menaquinone catabolic process |
| GO_0006631 | Biological process | fatty acid metabolic process |
| GO_0036101 | Biological process | leukotriene B4 catabolic process |
| GO_0003095 | Biological process | pressure natriuresis |
| GO_0019373 | Biological process | epoxygenase P450 pathway |
| GO_0001676 | Biological process | long-chain fatty acid metabolic process |
| GO_0042376 | Biological process | phylloquinone catabolic process |
| GO_0019369 | Biological process | arachidonic acid metabolic process |
| GO_0016324 | Cellular component | apical plasma membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0018685 | Molecular function | alkane 1-monooxygenase activity |
| GO_0070330 | Molecular function | aromatase activity |
| GO_0050051 | Molecular function | leukotriene-B4 20-monooxygenase activity |
| GO_0004497 | Molecular function | monooxygenase activity |
| GO_0005506 | Molecular function | iron ion binding |
| GO_0020037 | Molecular function | heme binding |
| GO_0008392 | Molecular function | arachidonic acid epoxygenase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CYP4F12 |
| Protein name | Cytochrome P450, family 4, subfamily F, polypeptide 12 Cytochrome P450 4F12 (EC 1.14.14.1) (CYPIVF12) Cytochrome P450 family 4 subfamily F member 12 |
| Synonyms | UNQ568/PRO1129 |
| Description | FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of endogenous polyunsaturated fatty acids (PUFAs). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds, with preference for omega-2 position. Metabolizes (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) toward 18-hydroxy arachidonate . Catalyzes the epoxidation of double bonds of PUFAs such as docosapentaenoic and docosahexaenoic acids . Has low omega-hydroxylase activity toward leukotriene B4 and arachidonate . Involved in the metabolism of xenobiotics. Catalyzes the hydroxylation of the antihistamine drug ebastine . . |
| Accessions | ENST00000551607.5 Q9HCS2 F8VU50 ENST00000550308.6 [Q9HCS2-1] ENST00000548237.5 Q8IV39 F8VZP1 ENST00000324632.10 [Q9HCS2-1] ENST00000547332.5 ENST00000548435.5 [Q9HCS2-2] ENST00000517734.5 [Q9HCS2-2] F8VR75 |
