CYP2R1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CYP2R1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYP2R1 at tissue level.

III. Associated gene sets

GO_0006805Biological processxenobiotic metabolic process
GO_0006766Biological processvitamin metabolic process
GO_0006082Biological processorganic acid metabolic process
GO_0036378Biological processcalcitriol biosynthetic process from calciol
GO_0010164Biological processresponse to cesium ion
GO_0010212Biological processresponse to ionizing radiation
GO_0042359Biological processvitamin D metabolic process
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005737Cellular componentcytoplasm
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_1902271Molecular functionD3 vitamins binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0005506Molecular functioniron ion binding
GO_0030343Molecular functionvitamin D3 25-hydroxylase activity
GO_0008395Molecular functionsteroid hydroxylase activity
GO_0020037Molecular functionheme binding
GO_0016712Molecular functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

IV. Literature review

[source]
Gene nameCYP2R1
Protein nameCytochrome P450 family 2 subfamily R member 1
Vitamin D 25-hydroxylase (EC 1.14.14.24) (Cytochrome P450 2R1)
Synonyms
DescriptionFUNCTION: A cytochrome P450 monooxygenase involved in activation of vitamin D precursors. Catalyzes hydroxylation at C-25 of both forms of vitamin D, vitamin D(2) and D(3) (calciol) . Can metabolize vitamin D analogs/prodrugs 1alpha-hydroxyvitamin D(2) (doxercalciferol) and 1alpha-hydroxyvitamin D(3) (alfacalcidol) forming 25-hydroxy derivatives . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) . .

AccessionsE9PS56
Q6VVX0
ENST00000525015.1
ENST00000534686.5
ENST00000334636.10
E9PJT9
ENST00000530609.5
ENST00000532805.1
K7EMQ4
ENST00000532378.5