I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| hepatocyte | 4 studies | 32% ± 13% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| hepatocyte | 4 studies | 32% ± 13% |
Insufficient scRNA-seq data for expression of CYP2D6 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 13472.03 | 226 / 226 | 97% | 236.06 | 394 / 406 |
| ovary | 99% | 197.47 | 179 / 180 | 79% | 3.13 | 340 / 430 |
| esophagus | 87% | 92.38 | 1250 / 1445 | 90% | 2.96 | 165 / 183 |
| brain | 93% | 184.87 | 2457 / 2642 | 79% | 2.93 | 554 / 705 |
| thymus | 100% | 368.93 | 652 / 653 | 71% | 1.91 | 428 / 605 |
| stomach | 92% | 87.45 | 329 / 359 | 77% | 2.38 | 221 / 286 |
| intestine | 94% | 285.79 | 910 / 966 | 73% | 2.50 | 386 / 527 |
| prostate | 99% | 261.91 | 243 / 245 | 66% | 1.45 | 332 / 502 |
| lung | 96% | 100.11 | 552 / 578 | 69% | 2.69 | 793 / 1155 |
| pancreas | 94% | 84.19 | 307 / 328 | 68% | 1.61 | 121 / 178 |
| uterus | 95% | 130.89 | 161 / 170 | 66% | 2.69 | 303 / 459 |
| kidney | 100% | 187.38 | 89 / 89 | 45% | 1.14 | 407 / 901 |
| bladder | 86% | 62.62 | 18 / 21 | 57% | 1.51 | 288 / 504 |
| breast | 92% | 115.79 | 423 / 459 | 49% | 1.08 | 545 / 1118 |
| adrenal gland | 86% | 62.68 | 222 / 258 | 53% | 1.28 | 123 / 230 |
| skin | 74% | 114.79 | 1344 / 1809 | 28% | 0.55 | 134 / 472 |
| ureter | 0% | 0 | 0 / 0 | 100% | 1.56 | 1 / 1 |
| spleen | 98% | 182.07 | 237 / 241 | 0% | 0 | 0 / 0 |
| adipose | 87% | 70.35 | 1052 / 1204 | 0% | 0 | 0 / 0 |
| peripheral blood | 71% | 59.50 | 657 / 929 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 67% | 1.86 | 30 / 45 |
| heart | 49% | 26.13 | 422 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 49% | 27.88 | 651 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 48% | 0.80 | 14 / 29 |
| muscle | 20% | 9.45 | 160 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 5% | 0.07 | 4 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0033076 | Biological process | isoquinoline alkaloid metabolic process |
| GO_0009804 | Biological process | coumarin metabolic process |
| GO_0006805 | Biological process | xenobiotic metabolic process |
| GO_0008203 | Biological process | cholesterol metabolic process |
| GO_0051100 | Biological process | negative regulation of binding |
| GO_0009822 | Biological process | alkaloid catabolic process |
| GO_0016098 | Biological process | monoterpenoid metabolic process |
| GO_0009820 | Biological process | alkaloid metabolic process |
| GO_0042178 | Biological process | xenobiotic catabolic process |
| GO_0042572 | Biological process | retinol metabolic process |
| GO_0008210 | Biological process | estrogen metabolic process |
| GO_0042759 | Biological process | long-chain fatty acid biosynthetic process |
| GO_0070989 | Biological process | oxidative demethylation |
| GO_0008202 | Biological process | steroid metabolic process |
| GO_0019369 | Biological process | arachidonic acid metabolic process |
| GO_0090350 | Biological process | negative regulation of cellular organofluorine metabolic process |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0016712 | Molecular function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| GO_0062189 | Molecular function | anandamide 14,15 epoxidase activity |
| GO_0016491 | Molecular function | oxidoreductase activity |
| GO_0004497 | Molecular function | monooxygenase activity |
| GO_0005506 | Molecular function | iron ion binding |
| GO_0020037 | Molecular function | heme binding |
| GO_0062187 | Molecular function | anandamide 8,9 epoxidase activity |
| GO_0062188 | Molecular function | anandamide 11,12 epoxidase activity |
| Gene name | CYP2D6 |
| Protein name | Nonfunctional cytochrome P450 family 2 subfamily D polypeptide 6 (EC 1.14.14.1) Cytochrome P450 (EC 1.14.14.-) Nonfunctional cytochrome P450 family 2 subfamily D polypeptide 6 Cytochrome P450 2D6 (EC 1.14.14.1) Cytochrome P450 2D6 Cytochrome P450 IID6 Cytochrome P4502D6 CYP2D6 protein (Cytochrome P450, family 2, subfamily D, polypeptide 6) Cytochrome P450 2D6 (EC 1.14.14.-) (CYPIID6) (Cholesterol 25-hydroxylase) (Cytochrome P450-DB1) (Debrisoquine 4-hydroxylase) |
| Synonyms | CYP2DL1 LOC101929829 cyp2d6 hCG_41551 |
| Description | FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) . Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) . Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling . Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis . Catalyzes the oxidative transformations of all-trans retinol to all-trans retinal, a precursor for the active form all-trans-retinoic acid . Also involved in the oxidative metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. . |
| Accessions | A0A0F7KYR9 ENST00000636361.1 ENST00000625898.2 D5KNB5 Q38LG2 D3IP05 I1VC92 D5KN01 D0U5L8 D5KN64 ENST00000629640.1 A0A2L1K0F5 A0A2L1K0H6 D5KN61 H7BY38 ENST00000630793.2 D3IP04 Q38LF9 ENST00000607223.6 ENST00000636910.1 Q007T9 A0A2L1K0F2 ENST00000646114.2 Q2XND2 Q3KPF3 A0A1B0GUD8 A0A2L1K0I9 A0A0F7KZW3 C1ID54 A0A1B0GU72 A0A2L1K0F9 A0A2L1K0G2 ENST00000645361.2 [P10635-1] Q2XND3 C1ID52 D5KMU6 Q2XND0 ENST00000360124.9 ENST00000612990.2 ENST00000625976.2 A0A2L1K0H9 P10635 D5KMS0 D5KMQ2 ENST00000643124.2 A0A2L1K0H3 Q2XND8 D3IP03 Q007T8 Q6ICD8 D5KN50 Q38LG0 ENST00000635505.1 A0A2L1K0M4 A0A0F7L0X4 ENST00000607853.6 I1VC93 A0A2L1K0E8 ENST00000606649.2 D5KMR1 A9QKR9 A0A1B0GV74 ENST00000359033.4 [P10635-2] ENST00000634653.1 G9CGD2 D5KMU5 W5QSH4 A0A0G2JSD7 C4MDQ5 D5KND2 A0A2L1K0H8 D5KN10 ENST00000635028.1 ENST00000615454.4 ENST00000647083.2 ENST00000637987.1 Q6NWU0 A0A2L1K0G7 A0A0G2JLK7 D5KMZ1 |
