CYP19A1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CYP19A1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYP19A1 at tissue level.

III. Associated gene sets

GO_0006703Biological processestrogen biosynthetic process
GO_2000866Biological processpositive regulation of estradiol secretion
GO_0030879Biological processmammary gland development
GO_0032355Biological processresponse to estradiol
GO_0006949Biological processsyncytium formation
GO_0030540Biological processfemale genitalia development
GO_0002677Biological processnegative regulation of chronic inflammatory response
GO_0060736Biological processprostate gland growth
GO_0061370Biological processtestosterone biosynthetic process
GO_0016125Biological processsterol metabolic process
GO_0006694Biological processsteroid biosynthetic process
GO_0060065Biological processuterus development
GO_0010760Biological processnegative regulation of macrophage chemotaxis
GO_0006710Biological processandrogen catabolic process
GO_0008585Biological processfemale gonad development
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0070330Molecular functionaromatase activity
GO_0009055Molecular functionelectron transfer activity
GO_0016712Molecular functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO_0019825Molecular functionoxygen binding
GO_0005506Molecular functioniron ion binding
GO_0020037Molecular functionheme binding
GO_0008395Molecular functionsteroid hydroxylase activity

IV. Literature review

[source]
Gene nameCYP19A1
Protein nameAromatase (CYPXIX) (Cytochrome P450 19A1)
Cytochrome P450 family 19 subfamily A member 1
Aromatase (EC 1.14.14.14) (CYPXIX) (Cytochrome P-450AROM) (Cytochrome P450 19A1) (Estrogen synthase)
SynonymsARO1
CYAR
CYP19
DescriptionFUNCTION: A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively . Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid . Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen . Also displays 2-hydroxylase activity toward estrone . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) . .

AccessionsQ8IYG4
P11511
ENST00000559646.1
Q45RG7
ENST00000396402.6 [P11511-1]
ENST00000559653.1
H0YLS2
ENST00000557858.5 [P11511-2]
Q05CU4
H0YKN1
Q7Z471
H0YLP1
ENST00000558328.5
ENST00000439712.6
ENST00000559878.5 [P11511-1]
ENST00000405913.7 [P11511-2]
H0YK57
ENST00000396404.8 [P11511-1]
ENST00000453807.6
ENST00000559980.5
ENST00000561075.5
E7EQ08
ENST00000405011.6
E9PGZ6
ENST00000557934.5
H0YNJ7
E7EPL6