CUL9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0007088Biological processregulation of mitotic nuclear division
GO_0005829Cellular componentcytosol
GO_0031461Cellular componentcullin-RING ubiquitin ligase complex
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameCUL9
Protein nameCUL9 protein
RBR-type E3 ubiquitin transferase (EC 2.3.2.31)
Alternative protein CUL9
Cullin 9
Cullin-9 (CUL-9) (UbcH7-associated protein 1) (p53-associated parkin-like cytoplasmic protein)
SynonymsKIAA0708
H7AP1
PARC
DescriptionFUNCTION: Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 . Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function . .

AccessionsQ05C85
E9PEZ1
ENST00000372647.6
L8E9R8
H0YA00
ENST00000506830.5
ENST00000502719.5
Q8IWT3
H0Y8H9
ENST00000252050.9 [Q8IWT3-1]