CUL4B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0000209Biological processprotein polyubiquitination
GO_0042254Biological processribosome biogenesis
GO_0034644Biological processcellular response to UV
GO_0010498Biological processproteasomal protein catabolic process
GO_0031175Biological processneuron projection development
GO_0070914Biological processUV-damage excision repair
GO_0006974Biological processDNA damage response
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0048708Biological processastrocyte differentiation
GO_1900087Biological processpositive regulation of G1/S transition of mitotic cell cycle
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0010467Biological processgene expression
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0031464Cellular componentCul4A-RING E3 ubiquitin ligase complex
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0080008Cellular componentCul4-RING E3 ubiquitin ligase complex
GO_0005829Cellular componentcytosol
GO_0031465Cellular componentCul4B-RING E3 ubiquitin ligase complex
GO_0005634Cellular componentnucleus
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene nameCUL4B
Protein nameCullin-4B (CUL-4B)
Cullin 4B
SynonymshCG_40765
KIAA0695
DescriptionFUNCTION: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins . The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit . CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme . Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage . Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication . A number of DCX complexes (containing either TRPC4AP or DCAF12 as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation . The DCX(AMBRA1) complex is a master regulator of the transition from G1 to S cell phase by mediating ubiquitination of phosphorylated cyclin-D (CCND1, CCND2 and CCND3) . The DCX(AMBRA1) complex also acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes . Required for ubiquitination of cyclin E (CCNE1 or CCNE2), and consequently, normal G1 cell cycle progression . Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism . Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8 . With CUL4A, contributes to ribosome biogenesis . .

AccessionsENST00000681090.1
A0A7P0T809
ENST00000679844.1
A0A7P0T9C8
A0A7P0T9L3
A0A669KAU9
A0A7P0T8P8
ENST00000674137.11
K4DI93
A0A7P0T9D0
ENST00000673919.1
ENST00000371323.3 [Q13620-3]
A0A7P0T9R8
A0A7P0Z4E4
A0A669KBG9
A0A804CL36
ENST00000679432.1
A0A7P0T9P5
ENST00000681908.1
A0A7P0TAF9
ENST00000680988.1
A0A7P0Z439
ENST00000681253.1 [Q13620-2]
A0A7P0T894
ENST00000681652.1 [Q13620-2]
ENST00000404115.8
ENST00000680918.1
ENST00000680673.1 [Q13620-2]
ENST00000486604.1
ENST00000674073.2
A0A669KAX4
ENST00000681333.1
ENST00000679927.1
ENST00000681189.1
A0A7P0T954
ENST00000681869.1
ENST00000371322.11 [Q13620-1]
ENST00000681206.1
ENST00000681080.1
ENST00000680474.1
A0A7P0TAQ3
ENST00000679405.1
Q13620
ENST00000336592.11
A0A7P0T8W4
A0A7P0Z4G9