CTU2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CTU2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CTU2 at tissue level.

III. Associated gene sets

GO_0002098Biological processtRNA wobble uridine modification
GO_0034227Biological processtRNA thio-modification
GO_0032447Biological processprotein urmylation
GO_0002143Biological processtRNA wobble position uridine thiolation
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0016779Molecular functionnucleotidyltransferase activity
GO_0000049Molecular functiontRNA binding
GO_0016783Molecular functionsulfurtransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCTU2
Protein nameCytoplasmic tRNA 2-thiolation protein 2 (Cytosolic thiouridylase subunit 2)
Cytosolic thiouridylase subunit 2
Cytoplasmic tRNA 2-thiolation protein 2
SynonymsNCS2
C16orf84
DescriptionFUNCTION: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. .

FUNCTION: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. .

AccessionsH3BNM3
ENST00000453996.7 [Q2VPK5-1]
H3BPG4
ENST00000564921.1
ENST00000567949.5
ENST00000564105.5
ENST00000567316.1
H3BSW6
Q2VPK5
ENST00000312060.9 [Q2VPK5-5]
H3BNU5