CTU1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CTU1 at tissue level.

III. Associated gene sets

GO_0002098Biological processtRNA wobble uridine modification
GO_0034227Biological processtRNA thio-modification
GO_0032447Biological processprotein urmylation
GO_0002143Biological processtRNA wobble position uridine thiolation
GO_0002144Cellular componentcytosolic tRNA wobble base thiouridylase complex
GO_0005829Cellular componentcytosol
GO_0016779Molecular functionnucleotidyltransferase activity
GO_0000049Molecular functiontRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCTU1
Protein nameCytoplasmic tRNA 2-thiolation protein 1 (EC 2.7.7.-) (ATP-binding domain-containing protein 3) (Cancer-associated gene protein) (Cytoplasmic tRNA adenylyltransferase 1)
SynonymsATPBD3
NCS6
DescriptionFUNCTION: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. .

AccessionsENST00000421832.3
Q7Z7A3