CTDP1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CTDP1 at tissue level.

III. Associated gene sets

GO_0006470Biological processprotein dephosphorylation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0006368Biological processtranscription elongation by RNA polymerase II
GO_0051301Biological processcell division
GO_0061052Biological processnegative regulation of cell growth involved in cardiac muscle cell development
GO_0010458Biological processexit from mitosis
GO_0043923Biological processpositive regulation by host of viral transcription
GO_0030496Cellular componentmidbody
GO_0000922Cellular componentspindle pole
GO_0005813Cellular componentcentrosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0051233Cellular componentspindle midzone
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005819Cellular componentspindle
GO_0005634Cellular componentnucleus
GO_0004721Molecular functionphosphoprotein phosphatase activity
GO_0017018Molecular functionmyosin phosphatase activity
GO_0001096Molecular functionTFIIF-class transcription factor complex binding
GO_0030957Molecular functionTat protein binding
GO_0008420Molecular functionRNA polymerase II CTD heptapeptide repeat phosphatase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCTDP1
Protein nameRNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase)
protein-serine/threonine phosphatase (EC 3.1.3.16)
RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16)
SynonymsFCP1
DescriptionFUNCTION: Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. .

FUNCTION: This promotes the activity of RNA polymerase II. .

FUNCTION: This promotes the activity of RNA polymerase II. .

FUNCTION: This promotes the activity of RNA polymerase II. .

AccessionsA0A0J9YWB6
ENST00000632905.1
A0A0J9YWJ4
K7EPW4
ENST00000632932.1
ENST00000632450.1
A0A0A0MR03
ENST00000632301.1
ENST00000590635.5
ENST00000613122.5 [Q9Y5B0-1]
ENST00000299543.9
K7EJD2
ENST00000075430.11 [Q9Y5B0-4]
ENST00000591598.5
Q9Y5B0