CRTC2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CRTC2 at tissue level.

III. Associated gene sets

GO_0032793Biological processpositive regulation of CREB transcription factor activity
GO_0006094Biological processgluconeogenesis
GO_0051289Biological processprotein homotetramerization
GO_0042593Biological processglucose homeostasis
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0008140Molecular functioncAMP response element binding protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCRTC2
Protein nameCREB regulated transcription coactivator 2
CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2)
SynonymsTORC2
DescriptionFUNCTION: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). .

AccessionsENST00000461638.6
Q5T4K5
ENST00000368630.7
H0YDQ8
J3KNE6
ENST00000303569.10
Q53ET0
ENST00000368633.2