CRTC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097009Biological processenergy homeostasis
GO_0007613Biological processmemory
GO_0032793Biological processpositive regulation of CREB transcription factor activity
GO_0043153Biological processentrainment of circadian clock by photoperiod
GO_1902631Biological processnegative regulation of membrane hyperpolarization
GO_0051289Biological processprotein homotetramerization
GO_0048511Biological processrhythmic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016604Cellular componentnuclear body
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0008140Molecular functioncAMP response element binding protein binding

IV. Literature review

[source]
Gene nameCRTC1
Protein nameCREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1)
CREB regulated transcription coactivator 1
SynonymsMECT1
WAMTP1
TORC1
KIAA0616
DescriptionFUNCTION: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. .; FUNCTION: (Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). .

AccessionsENST00000338797.10 [Q6UUV9-2]
M0QXN6
ENST00000321949.13 [Q6UUV9-1]
ENST00000601916.1
M0QX46
ENST00000594658.5
Q6UUV9