CRAT report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CRAT at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CRAT at tissue level.

III. Associated gene sets

GO_0019254Biological processcarnitine metabolic process, CoA-linked
GO_0051791Biological processmedium-chain fatty acid metabolic process
GO_0046459Biological processshort-chain fatty acid metabolic process
GO_0033540Biological processfatty acid beta-oxidation using acyl-CoA oxidase
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005777Cellular componentperoxisome
GO_0005782Cellular componentperoxisomal matrix
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005739Cellular componentmitochondrion
GO_0003997Molecular functionacyl-CoA oxidase activity
GO_0008458Molecular functioncarnitine O-octanoyltransferase activity
GO_0004092Molecular functioncarnitine O-acetyltransferase activity

IV. Literature review

[source]
Gene nameCRAT
Protein nameCarnitine O-acetyltransferase
Carnitine O-acetyltransferase (Carnitine acetylase) (EC 2.3.1.137) (EC 2.3.1.7) (Carnitine acetyltransferase) (CAT) (CrAT)
SynonymsCAT1
DescriptionFUNCTION: Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation . Responsible for the synthesis of short- and branched-chain acylcarnitines . Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates . Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates . .

AccessionsENST00000415948.6
ENST00000681725.1
ENST00000680117.1
P43155
ENST00000681622.1
ENST00000679520.1
ENST00000458362.5
H0Y4Z7
ENST00000681040.1
ENST00000393384.3
ENST00000681627.1
A0A7P0T9R9
A0A7P0TAR1
A6PVN3
ENST00000681689.1
ENST00000680093.1
A0A7P0TAQ4
F2Z2C5
ENST00000681911.1
ENST00000441796.1
ENST00000681325.1
A0A7P0TBF3
ENST00000318080.7 [P43155-1]
A0A7P0T9E7
ENST00000455396.2
ENST00000455830.2
B7ZBP5