CPTP | OmnibusX

Name	Number of supported studies	Average coverage
epithelial cell	4 studies	20% ± 3%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of CPTP at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	3607.55	226 / 226	100%	52.75	406 / 406
pancreas	100%	1041.21	328 / 328	100%	43.59	178 / 178
uterus	100%	1627.76	170 / 170	100%	54.22	459 / 459
esophagus	100%	2519.21	1443 / 1445	100%	62.41	183 / 183
thymus	100%	1578.72	652 / 653	100%	49.33	605 / 605
ovary	99%	1071.62	179 / 180	100%	63.96	430 / 430
brain	99%	1506.87	2627 / 2642	100%	37.41	705 / 705
kidney	100%	2540.18	89 / 89	99%	43.13	895 / 901
prostate	100%	2044.64	245 / 245	99%	55.17	498 / 502
skin	100%	2573.79	1809 / 1809	99%	52.58	468 / 472
intestine	100%	2222.89	965 / 966	99%	51.06	523 / 527
bladder	100%	1496.81	21 / 21	98%	58.61	496 / 504
stomach	99%	2354.62	357 / 359	99%	50.50	283 / 286
breast	100%	1815.53	459 / 459	98%	45.70	1100 / 1118
lung	98%	1366.49	566 / 578	99%	44.65	1139 / 1155
adrenal gland	100%	1874.93	258 / 258	95%	29.26	219 / 230
eye	0%	0	0 / 0	100%	47.14	80 / 80
lymph node	0%	0	0 / 0	100%	41.26	29 / 29
spleen	100%	2134.51	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	50.14	45 / 45
ureter	0%	0	0 / 0	100%	79.69	1 / 1
heart	100%	3669.88	860 / 861	0%	0	0 / 0
adipose	100%	1608.37	1202 / 1204	0%	0	0 / 0
muscle	99%	2154.18	795 / 803	0%	0	0 / 0
blood vessel	99%	1255.31	1319 / 1335	0%	0	0 / 0
peripheral blood	88%	1141.61	822 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0010507	Biological process	negative regulation of autophagy
GO_0120009	Biological process	intermembrane lipid transfer
GO_1902389	Biological process	ceramide 1-phosphate transport
GO_0035627	Biological process	ceramide transport
GO_0046836	Biological process	glycolipid transport
GO_0032691	Biological process	negative regulation of interleukin-1 beta production
GO_1900226	Biological process	negative regulation of NLRP3 inflammasome complex assembly
GO_0010008	Cellular component	endosome membrane
GO_0005829	Cellular component	cytosol
GO_0005794	Cellular component	Golgi apparatus
GO_0005886	Cellular component	plasma membrane
GO_0005640	Cellular component	nuclear outer membrane
GO_1902388	Molecular function	ceramide 1-phosphate transfer activity
GO_1902387	Molecular function	ceramide 1-phosphate binding
GO_0005543	Molecular function	phospholipid binding

Gene name	CPTP
Protein name	Ceramide-1-phosphate transfer protein (CPTP) (Glycolipid transfer protein domain-containing protein 1) (GLTP domain-containing protein 1) Ceramide-1-phosphate transfer protein (Glycolipid transfer protein domain-containing protein 1)
Synonyms	GLTPD1
Description	FUNCTION: Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles . Regulates autophagy, inflammasome mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis . .
Accessions	ENST00000488011.1 J3KST3 S4S694 Q5TA50 ENST00000343938.9

CPTP report