COX18 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008535Biological processrespiratory chain complex IV assembly
GO_0033617Biological processmitochondrial cytochrome c oxidase assembly
GO_0051204Biological processprotein insertion into mitochondrial membrane
GO_0032979Biological processprotein insertion into mitochondrial inner membrane from matrix
GO_0005743Cellular componentmitochondrial inner membrane
GO_0032977Molecular functionmembrane insertase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCOX18
Protein nameCOX18 protein (Cytochrome c oxidase assembly factor COX18)
Cytochrome c oxidase assembly protein COX18, mitochondrial (COX18Hs) (Cytochrome c oxidase assembly protein 18)
SynonymsOXA1L2
DescriptionFUNCTION: Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT-CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT-CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase). .

AccessionsENST00000449739.6 [Q8N8Q8-3]
ENST00000507544.3
Q8N8Q8
ENST00000510031.1 [Q8N8Q8-2]
B7ZL88
ENST00000295890.8 [Q8N8Q8-1]