COX15 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1902600Biological processproton transmembrane transport
GO_0017004Biological processcytochrome complex assembly
GO_0006783Biological processheme biosynthetic process
GO_0006784Biological processheme A biosynthetic process
GO_0007585Biological processrespiratory gaseous exchange by respiratory system
GO_0070069Cellular componentcytochrome complex
GO_0005746Cellular componentmitochondrial respirasome
GO_0005654Cellular componentnucleoplasm
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005739Cellular componentmitochondrion
GO_0016653Molecular functionoxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
GO_0004129Molecular functioncytochrome-c oxidase activity
GO_0020037Molecular functionheme binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0016627Molecular functionoxidoreductase activity, acting on the CH-CH group of donors

IV. Literature review

[source]
Gene nameCOX15
Protein nameHeme A synthase COX15 (HAS) (EC 1.17.99.9) (Cytochrome c oxidase assembly protein COX15 homolog)
Synonyms
DescriptionFUNCTION: Catalyzes the second reaction in the biosynthesis of heme A, a prosthetic group of mitochondrial cytochrome c oxidase (CcO) . Heme A is synthesized from heme B by two sequential enzymatic reactions catalyzed by heme O synthase (HOS) and heme A synthase (HAS). HAS catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8, in a reaction that involves matrix ferredoxin and ferredoxin reductase. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A (By similarity). .

AccessionsQ7KZN9
ENST00000016171.6 [Q7KZN9-1]
ENST00000370483.9 [Q7KZN9-2]