CORIN | OmnibusX

Name	Number of supported studies	Average coverage
cardiac muscle cell	5 studies	39% ± 9%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of CORIN at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	97%	544.54	238 / 245	56%	2.06	281 / 502
lung	82%	191.40	475 / 578	34%	0.78	392 / 1155
breast	49%	131.02	225 / 459	62%	2.40	694 / 1118
uterus	90%	758.14	153 / 170	12%	0.31	56 / 459
heart	99%	4714.34	849 / 861	0%	0	0 / 0
skin	94%	767.31	1700 / 1809	4%	0.08	19 / 472
esophagus	67%	126.49	962 / 1445	25%	0.53	45 / 183
stomach	53%	80.85	189 / 359	34%	0.87	96 / 286
spleen	82%	283.39	198 / 241	0%	0	0 / 0
bladder	62%	316.67	13 / 21	19%	0.49	97 / 504
pancreas	12%	13.60	39 / 328	69%	2.59	123 / 178
blood vessel	77%	153.90	1033 / 1335	0%	0	0 / 0
intestine	43%	60.17	416 / 966	29%	0.80	155 / 527
kidney	46%	106.12	41 / 89	7%	0.17	59 / 901
ovary	33%	113.05	59 / 180	16%	0.32	67 / 430
adipose	24%	52.23	289 / 1204	0%	0	0 / 0
thymus	16%	15.86	103 / 653	8%	0.28	46 / 605
adrenal gland	9%	9.15	22 / 258	15%	0.58	34 / 230
brain	11%	11.99	289 / 2642	1%	0.01	5 / 705
peripheral blood	10%	16.12	97 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	9%	0.17	4 / 45
liver	1%	1.09	2 / 226	7%	0.27	27 / 406
muscle	3%	5.60	25 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0003050	Biological process	regulation of systemic arterial blood pressure by atrial natriuretic peptide
GO_0016486	Biological process	peptide hormone processing
GO_0008217	Biological process	regulation of blood pressure
GO_1903779	Biological process	regulation of cardiac conduction
GO_0007565	Biological process	female pregnancy
GO_0035813	Biological process	regulation of renal sodium excretion
GO_0009986	Cellular component	cell surface
GO_0015629	Cellular component	actin cytoskeleton
GO_0016604	Cellular component	nuclear body
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0004175	Molecular function	endopeptidase activity
GO_0004252	Molecular function	serine-type endopeptidase activity
GO_0005515	Molecular function	protein binding

Gene name	CORIN
Protein name	Atrial natriuretic peptide-converting enzyme (EC 3.4.21.-) (Corin) (Heart-specific serine proteinase ATC2) (Pro-ANP-converting enzyme) (Transmembrane protease serine 10) [Cleaved into: Atrial natriuretic peptide-converting enzyme, N-terminal propeptide; Atrial natriuretic peptide-converting enzyme, activated protease fragment; Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment] Corin, serine peptidase
Synonyms	TMPRSS10 CRN
Description	FUNCTION: Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing . Converts through proteolytic cleavage the non-functional propeptides NPPA and NPPB into their active hormones, ANP and BNP(1-32) respectively, thereby regulating blood pressure in the heart and promoting natriuresis, diuresis and vasodilation . Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus . Also acts as a regulator of sodium reabsorption in kidney (By similarity). .; FUNCTION: [Isoform 2]: Has weaker endopeptidase activity compared to isoform 1.
Accessions	J3KR88 ENST00000502252.5 E7EQE7 ENST00000508498.5 ENST00000273857.9 [Q9Y5Q5-1] J3KR83 ENST00000610355.4 Q9Y5Q5 ENST00000505909.5 ENST00000504584.1 J3KR90 A0A087X1D5

CORIN report