COQ6 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of COQ6 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	332.26	1445 / 1445	100%	2.47	183 / 183
liver	100%	327.23	226 / 226	100%	3.01	406 / 406
prostate	100%	400.24	245 / 245	100%	4.70	502 / 502
thymus	100%	437.94	653 / 653	100%	2.89	604 / 605
ovary	100%	376.07	180 / 180	100%	3.17	429 / 430
intestine	100%	375.06	966 / 966	100%	2.73	525 / 527
adrenal gland	100%	1039.28	258 / 258	100%	4.01	229 / 230
bladder	100%	402.67	21 / 21	99%	2.93	501 / 504
breast	100%	413.61	459 / 459	99%	3.71	1111 / 1118
uterus	100%	389.60	170 / 170	99%	2.94	456 / 459
stomach	100%	326.98	359 / 359	99%	2.47	284 / 286
kidney	100%	447.93	89 / 89	99%	3.18	894 / 901
brain	99%	282.22	2624 / 2642	100%	3.06	704 / 705
skin	100%	300.34	1808 / 1809	99%	2.51	465 / 472
lung	98%	255.79	569 / 578	99%	2.60	1146 / 1155
pancreas	97%	137.45	319 / 328	97%	2.48	172 / 178
adipose	100%	351.39	1204 / 1204	0%	0	0 / 0
blood vessel	100%	324.54	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	2.32	29 / 29
muscle	100%	515.38	803 / 803	0%	0	0 / 0
spleen	100%	360.76	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	1.44	1 / 1
heart	99%	502.83	851 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	95%	3.00	76 / 80
tonsil	0%	0	0 / 0	91%	2.16	41 / 45
peripheral blood	65%	123.10	601 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0006744	Biological process	ubiquinone biosynthetic process
GO_0042995	Cellular component	cell projection
GO_0031314	Cellular component	extrinsic component of mitochondrial inner membrane
GO_0110142	Cellular component	ubiquinone biosynthesis complex
GO_0005794	Cellular component	Golgi apparatus
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0071949	Molecular function	FAD binding
GO_0016709	Molecular function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO_0008681	Molecular function	2-octaprenyl-6-methoxyphenol hydroxylase activity
GO_0016491	Molecular function	oxidoreductase activity
GO_0005515	Molecular function	protein binding
GO_0106364	Molecular function	4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity

Gene name	COQ6
Protein name	Coenzyme Q6, monooxygenase Coenzyme Q6 homolog, monooxygenase (Yeast), isoform CRA_a (Coenzyme Q6, monooxygenase) Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial (EC 1.14.13.-) (Coenzyme Q10 monooxygenase 6)
Synonyms	CGI-10 hCG_21715
Description	FUNCTION: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-hexaprenyl-4-hydroxybenzoic acid (HHB) to 3-hexaprenyl-4,5-dihydroxybenzoic acid (DHHB). The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6 (By similarity). Is able to perform the deamination reaction at C4 of 3-hexaprenyl-4-amino-5-hydroxybenzoic acid (HHAB) to produce DHHB when expressed in yeast cells lacking COQ9, even if utilization of para-aminobenzoic acid (pABA) involving C4-deamination seems not to occur in bacteria, plants and mammals, where only C5 hydroxylation of HHB has been shown . .
Accessions	Q9Y2Z9 A0A0D9SFJ1 ENST00000334571.7 [Q9Y2Z9-1] G3V4A6 G3V2L5 G3V3A1 ENST00000554341.6 ENST00000629426.2 ENST00000554920.5 ENST00000554320.1 ENST00000394026.8 [Q9Y2Z9-3] ENST00000555196.5 ENST00000557584.5 G3V3L0 G3V434

COQ6 report