CMTM4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016020Cellular componentmembrane
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCMTM4
Protein nameCKLF like MARVEL transmembrane domain containing 4
CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine-like factor superfamily member 4)
SynonymsCKLFSF4
DescriptionFUNCTION: Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation. .

AccessionsENST00000330687.8 [Q8IZR5-1]
Q8IZR5
ENST00000394106.7 [Q8IZR5-2]
ENST00000561680.5
J3QRP2
ENST00000563952.1 [Q8IZR5-3]