CLPX report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046034Biological processATP metabolic process
GO_0006457Biological processprotein folding
GO_0006508Biological processproteolysis
GO_0051603Biological processproteolysis involved in protein catabolic process
GO_0009368Cellular componentendopeptidase Clp complex
GO_0042645Cellular componentmitochondrial nucleoid
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0005743Cellular componentmitochondrial inner membrane
GO_0009841Cellular componentmitochondrial endopeptidase Clp complex
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0004176Molecular functionATP-dependent peptidase activity
GO_0016504Molecular functionpeptidase activator activity
GO_0051082Molecular functionunfolded protein binding
GO_0140662Molecular functionATP-dependent protein folding chaperone
GO_0008270Molecular functionzinc ion binding
GO_0005524Molecular functionATP binding
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameCLPX
Protein nameCaseinolytic mitochondrial matrix peptidase chaperone subunit X
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
Synonyms
DescriptionFUNCTION: ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP . Targets specific substrates for degradation by the Clp complex . Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure . ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis . Important for efficient erythropoiesis through up-regulation of heme biosynthesis . .

AccessionsENST00000559218.1
ENST00000300107.7
H0YM48
ENST00000559152.5
O76031
H0YK07