CLK2 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of CLK2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4060.84	1445 / 1445	100%	40.02	183 / 183
ovary	100%	6257.41	180 / 180	100%	61.78	430 / 430
prostate	100%	6534.88	245 / 245	100%	36.86	502 / 502
stomach	100%	3756.89	359 / 359	100%	32.43	286 / 286
lung	100%	4329.59	578 / 578	100%	45.73	1154 / 1155
intestine	100%	4782.97	966 / 966	100%	32.91	526 / 527
skin	100%	4017.69	1809 / 1809	100%	46.14	471 / 472
uterus	100%	6223.27	170 / 170	100%	58.34	458 / 459
bladder	100%	4638.57	21 / 21	100%	48.00	502 / 504
breast	100%	4785.71	459 / 459	100%	49.42	1113 / 1118
thymus	100%	7964.90	653 / 653	100%	44.10	602 / 605
pancreas	100%	3262.73	327 / 328	99%	42.71	176 / 178
adrenal gland	100%	6335.27	258 / 258	98%	29.83	226 / 230
liver	100%	3252.94	226 / 226	97%	28.91	393 / 406
brain	95%	2253.88	2500 / 2642	100%	37.29	705 / 705
kidney	100%	5024.96	89 / 89	94%	31.12	850 / 901
adipose	100%	4052.86	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	50.98	29 / 29
spleen	100%	8959.39	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	37.42	45 / 45
ureter	0%	0	0 / 0	100%	42.37	1 / 1
blood vessel	100%	3295.06	1333 / 1335	0%	0	0 / 0
heart	99%	2005.95	854 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	99%	31.68	79 / 80
peripheral blood	96%	2874.79	893 / 929	0%	0	0 / 0
muscle	95%	1455.64	760 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0043484	Biological process	regulation of RNA splicing
GO_0018108	Biological process	peptidyl-tyrosine phosphorylation
GO_0006468	Biological process	protein phosphorylation
GO_0046777	Biological process	protein autophosphorylation
GO_0045721	Biological process	negative regulation of gluconeogenesis
GO_0010212	Biological process	response to ionizing radiation
GO_0016607	Cellular component	nuclear speck
GO_0016604	Cellular component	nuclear body
GO_0005654	Cellular component	nucleoplasm
GO_0005634	Cellular component	nucleus
GO_0004713	Molecular function	protein tyrosine kinase activity
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0004712	Molecular function	protein serine/threonine/tyrosine kinase activity
GO_0005515	Molecular function	protein binding
GO_0042802	Molecular function	identical protein binding
GO_0106310	Molecular function	protein serine kinase activity
GO_0005524	Molecular function	ATP binding

Gene name	CLK2
Protein name	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2) dual-specificity kinase (EC 2.7.12.1)
Synonyms	hCG_15308
Description	FUNCTION: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN . .
Accessions	ENST00000368361.9 [P49760-1] ENST00000572269.5 [P49760-3] Q9BRG8 ENST00000355560.4 ENST00000576584.1 B7Z8N6 P49760 B1AVT0 A8K7I0 ENST00000361168.9 [P49760-3] ENST00000574445.5 [P49760-1]

CLK2 report