I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| ciliated cell | 5 studies | 30% ± 15% | |
| Mueller cell | 3 studies | 39% ± 8% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| ciliated cell | 5 studies | 30% ± 15% | |
| Mueller cell | 3 studies | 39% ± 8% |
Insufficient scRNA-seq data for expression of CLGN at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 96% | 1223.16 | 234 / 245 | 99% | 73.61 | 499 / 502 |
| brain | 77% | 359.44 | 2025 / 2642 | 71% | 10.48 | 502 / 705 |
| adrenal gland | 36% | 100.44 | 93 / 258 | 83% | 60.60 | 191 / 230 |
| liver | 50% | 256.23 | 114 / 226 | 53% | 14.08 | 214 / 406 |
| heart | 98% | 3506.09 | 841 / 861 | 0% | 0 | 0 / 0 |
| breast | 28% | 68.03 | 127 / 459 | 69% | 27.57 | 769 / 1118 |
| ovary | 5% | 16.33 | 9 / 180 | 80% | 26.91 | 345 / 430 |
| esophagus | 69% | 214.70 | 991 / 1445 | 14% | 1.73 | 26 / 183 |
| uterus | 35% | 98.92 | 60 / 170 | 41% | 10.07 | 187 / 459 |
| intestine | 60% | 255.14 | 579 / 966 | 8% | 0.97 | 41 / 527 |
| tonsil | 0% | 0 | 0 / 0 | 58% | 19.57 | 26 / 45 |
| pancreas | 37% | 69.06 | 122 / 328 | 18% | 4.14 | 32 / 178 |
| lung | 19% | 44.85 | 107 / 578 | 30% | 5.85 | 350 / 1155 |
| stomach | 35% | 260.17 | 126 / 359 | 12% | 1.69 | 35 / 286 |
| bladder | 19% | 69.57 | 4 / 21 | 13% | 2.81 | 67 / 504 |
| skin | 17% | 56.10 | 303 / 1809 | 9% | 1.12 | 42 / 472 |
| kidney | 2% | 6.54 | 2 / 89 | 22% | 3.94 | 200 / 901 |
| thymus | 1% | 3.98 | 7 / 653 | 12% | 1.20 | 73 / 605 |
| lymph node | 0% | 0 | 0 / 0 | 10% | 0.88 | 3 / 29 |
| adipose | 3% | 5.11 | 37 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 2% | 10.57 | 22 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.13 | 1 / 80 |
| muscle | 1% | 3.03 | 10 / 803 | 0% | 0 | 0 / 0 |
| spleen | 1% | 2.53 | 3 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 1% | 2.33 | 10 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007339 | Biological process | binding of sperm to zona pellucida |
| GO_0006457 | Biological process | protein folding |
| GO_0007338 | Biological process | single fertilization |
| GO_0036503 | Biological process | ERAD pathway |
| GO_0065003 | Biological process | protein-containing complex assembly |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0044183 | Molecular function | protein folding chaperone |
| GO_0051082 | Molecular function | unfolded protein binding |
| GO_0005509 | Molecular function | calcium ion binding |
| Gene name | CLGN |
| Protein name | Alternative protein CLGN Calmegin |
| Synonyms | |
| Description | FUNCTION: Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity). . |
| Accessions | ENST00000325617.10 [O14967-1] ENST00000509477.1 O14967 D6RAZ4 ENST00000414773.5 [O14967-1] L8E7N0 |
