CLDN16 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CLDN16 at tissue level.

III. Associated gene sets

GO_0030001Biological processmetal ion transport
GO_0030003Biological processintracellular monoatomic cation homeostasis
GO_0010496Biological processintercellular transport
GO_0016338Biological processcalcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
GO_0007155Biological processcell adhesion
GO_0070830Biological processbicellular tight junction assembly
GO_1903830Biological processmagnesium ion transmembrane transport
GO_0005886Cellular componentplasma membrane
GO_0005923Cellular componentbicellular tight junction
GO_0015095Molecular functionmagnesium ion transmembrane transporter activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0005198Molecular functionstructural molecule activity

IV. Literature review

[source]
Gene nameCLDN16
Protein nameClaudin 16
Claudin-16 (Paracellin-1) (PCLN-1)
SynonymsPCLN1
DescriptionFUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors.

AccessionsENST00000456423.2
ENST00000264734.3
Q9Y5I7
F6SGM4