CLDN15 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006811Biological processmonoatomic ion transport
GO_0016338Biological processcalcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
GO_0007155Biological processcell adhesion
GO_0070830Biological processbicellular tight junction assembly
GO_0005886Cellular componentplasma membrane
GO_0016328Cellular componentlateral plasma membrane
GO_0005923Cellular componentbicellular tight junction
GO_0042802Molecular functionidentical protein binding
GO_0005198Molecular functionstructural molecule activity

IV. Literature review

[source]
Gene nameCLDN15
Protein nameClaudin-15
Claudin
Synonyms
DescriptionFUNCTION: Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects against Cl(-) ions. Plays an important role in paracellular Na(+) transport in the intestine and in Na(+) homeostasis. Required for normal Na(+)-dependent intestinal nutrient uptake. .

FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. .

FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. .

FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. .

FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. .

AccessionsENST00000611078.4
C9J3Z2
ENST00000433833.1
ENST00000401528.5
ENST00000412417.1
ENST00000414035.5
Q96FX9
P56746
C9JHQ4
ENST00000308344.10
H7C2D7