CLDN10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006811Biological processmonoatomic ion transport
GO_0043269Biological processregulation of monoatomic ion transport
GO_0016338Biological processcalcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
GO_0007155Biological processcell adhesion
GO_0070830Biological processbicellular tight junction assembly
GO_0005737Cellular componentcytoplasm
GO_0005886Cellular componentplasma membrane
GO_0005923Cellular componentbicellular tight junction
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0005198Molecular functionstructural molecule activity

IV. Literature review

[source]
Gene nameCLDN10
Protein nameClaudin-10 (Oligodendrocyte-specific protein-like) (OSP-like)
Claudin 10
Synonyms
DescriptionFUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in the regulation of paracellular epithelia permeability to ions in multiple organs. It acts as a paracellular ion channel probably forming permselective pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function . .

AccessionsP78369
ENST00000376873.7 [P78369-2]
ENST00000376855.1
ENST00000299339.3 [P78369-1]
Q5W075