CLCN7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1902476Biological processchloride transmembrane transport
GO_0030321Biological processtransepithelial chloride transport
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005765Cellular componentlysosomal membrane
GO_0034707Cellular componentchloride channel complex
GO_0016020Cellular componentmembrane
GO_0015297Molecular functionantiporter activity
GO_0005247Molecular functionvoltage-gated chloride channel activity
GO_0005515Molecular functionprotein binding
GO_0015108Molecular functionchloride transmembrane transporter activity
GO_0005254Molecular functionchloride channel activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameCLCN7
Protein nameChloride channel 7, isoform CRA_c (Chloride voltage-gated channel 7)
Chloride channel protein
CLCN7 protein
H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7)
Chloride voltage-gated channel 7
SynonymshCG_42716
DescriptionFUNCTION: Slowly voltage-gated channel mediating the exchange of chloride ions against protons . Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH . The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). .

AccessionsA0A8V8TPE0
ENST00000382745.9 [P51798-1]
ENST00000699947.1
Q96RY8
ENST00000564568.1
ENST00000569851.6
I3L470
Q2VPA2
P51798
A0A8V8TQF3
H0Y2M6
ENST00000262318.12
H3BNG8
ENST00000699948.1
Q9BRN4