CLCN1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CLCN1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CLCN1 at tissue level.

III. Associated gene sets

GO_1902476Biological processchloride transmembrane transport
GO_0006936Biological processmuscle contraction
GO_0006821Biological processchloride transport
GO_0019227Biological processneuronal action potential propagation
GO_0042383Cellular componentsarcolemma
GO_0034707Cellular componentchloride channel complex
GO_0005886Cellular componentplasma membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0005247Molecular functionvoltage-gated chloride channel activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCLCN1
Protein nameUncharacterized protein CLCN1
Chloride channel protein 1 (ClC-1) (Chloride channel protein, skeletal muscle)
Chloride voltage-gated channel 1
SynonymsCLC1
DescriptionFUNCTION: Voltage-gated chloride channel . Plays an important role in membrane repolarization in skeletal muscle cells after muscle contraction. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (Probable). The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable). .

AccessionsH7C0N6
Q75L28
P35523
A0A3B3IU72
ENST00000455478.6
ENST00000343257.7
ENST00000432192.6
ENST00000650516.2
H7C1F4